Development of boron neutron capture therapy targeting gastrointestinal cancer and search for biomarkers of its efficacy

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Okayama University
• Principal Investigator: Teraishi Fuminori 岡山大学, 大学病院, 講師 (40432661)
• Co-Investigator(Kenkyū-buntansha): 藤原 俊義 岡山大学, 医歯薬学域, 教授 (00304303) ; 道上 宏之 岡山大学, 中性子医療研究センター, 准教授 (20572499) ; 重安 邦俊 岡山大学, 大学病院, 助教 (70544071)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ホウ素中性子捕捉療法 / 膵がん / ホウ素薬剤 / グルコース輸送体 / グルコースBSH

Outline of Final Research Achievements

Boron Neutron Capture Therapy (BNCT) is a next-generation particle therapy in which boron is incorporated into cancer cells and selectively killed by neutron irradiation. In this study, glucose BSH, a novel BNCT agent, was administered to a pancreatic cancer cell lines, and boron uptake in cancer cells was confirmed. Subsequently, as a BNCT evaluation experiment in vitro using the novel BNCT agent, pancreatic cancer cell lines that had taken up glucose BSH were irradiated with neutrons, and the high cell-killing effect was confirmed. Furthermore, in vivo experiments were conducted in a mouse model of subcutaneous tumor of a pancreatic cancer cell line, in which glucose BSH was administered followed by neutron irradiation, and it was confirmed that the agent had a tumor growth inhibitory effect.

Free Research Field

消化器外科

Academic Significance and Societal Importance of the Research Achievements

本研究で、膵がん細胞株においてBNCTによる抗腫瘍効果がin vitro、in vivoで確認できた。脳腫瘍に対するBNCTは病院設置型加速器を用いて臨床試験が行われている段階であり、研究レベルより一般治療への移行が間近であり、これまでBNCTの有用性が報告されている脳腫瘍、悪性黒色腫、頭頸部がんに加え、膵がんに対するBNCTの臨床応用の可能性を示すことができた。