2023 Fiscal Year Final Research Report

Elucidation of the mechanism of cardiac fibrosis with a focus on endocardial fibrosis and development of its treatment

Research Project

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Project/Area Number	19K09238
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 55030:Cardiovascular surgery-related
Research Institution	The University of Tokyo
Principal Investigator	Shimada Shogo 東京大学, 医学部附属病院, 講師 (70812452)
Co-Investigator(Kenkyū-buntansha)	小野稔東京大学, 医学部附属病院, 教授 (40270871) 平田康隆東京大学, 医学部附属病院, 准教授 (70562601) 小前兵衛東京大学, 医学部附属病院, 助教 (50788883)
Project Period (FY)	2019-04-01 – 2024-03-31
Keywords	心内膜線維弾性症 / ラット異所性心移植 / 異種心移植
Outline of Final Research Achievements	To create an animal model of endocardial fibrosis, the following surgical techniques for animal experiments were newly established. (1) Rat heterotopic abdominal heart transplantation model with indroducing aortic regurgitation in a donor heart: A donor rat heart is removed, aortic regurgitation is introduced, and then transplanted into the abdomen of the recipient rat. The transplanted donor heart is dilated due to aortic regurgitation, resulting in fibrosis of the endocardium. (2) Rat-rabbit heterotopic heart transplantation model: A model in which a young rabbit is used as a donor and the removed heart is transplanted into the abdomen of an immunodeficient rat recipient.
Free Research Field	心臓外科
Academic Significance and Societal Importance of the Research Achievements	本研究では、免疫不全ラットを用いても異種移植モデルでの急性拒絶反応を回避することができないことが判明し、当初の目的である動物モデル作成には至らなかった。一方で、上記モデル作成への過程で再現性のあるラット異所性心移植大動脈弁閉鎖不全モデルを確立することができた。今後、心内膜の線維化メカニズムの解明やその治療法開発に役立つ成果と言える。