Novel classification system for assesing risk of progressive ascending aortic dialation associated with bicuspid aortic valve

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09277
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Hattori Kaoru 東京女子医科大学, 医学部, 助教 (30724439)
• Co-Investigator(Kenkyū-buntansha): 岩崎 清隆 早稲田大学, 理工学術院, 教授 (20339691) ; 新浪 博 東京女子医科大学, 医学部, 教授 (30241079)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 大動脈二尖弁 / 上行大動脈瘤 / 拍動循環システム / 4D-flow MRI

Outline of Final Research Achievements

In this study, morphotype-specific valve-devising apparatuses was developed to create aortic valve models, and an MRI-compatible pulsatile flow circulation system was developed to quantify the aortic valvular outflow jet. This study elucidated that bicuspid symmetry and the position of smaller leaflet were determinant factors of the characteristics of aortic valvular outflow jet.

Free Research Field

心臓血管外科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果は大動脈二尖弁の弁形態が上行大動脈瘤の瘤径拡大リスクを層別化するための指標として有用であることを示唆し、個々の瘤径拡大リスクに基づいた治療を提供するための新たな治療指針の作成に寄与し得るものと推察された。