2021 Fiscal Year Final Research Report
Analysis of invasion and metastasis mechanisms of lung adenocarcinomas and its application to novel therapeutics using an established cell line
| Project/Area Number |
19K09312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55040:Respiratory surgery-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三窪 将史 北里大学, 医学部, 講師 (90723940)
内藤 雅仁 北里大学, 医学部, 助教 (50648730)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 肺癌 / 腺癌 / 微小乳頭状 / 細胞株 / 転移 / 浸潤 / 細胞接着 |
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| Outline of Final Research Achievements |
Micropapillary lung adenocarcinoma (MPA) shows more invasiveness and poorer prognosis than papillary adenocarcinomas without an MPA pattern. To clarify the mechanism, we investigated the molecular features in a cell line (KU-Lu-MPPt3) established from the MPA tissue. We identified some genes associated with cancer metastasis and invasion, and we found that inhibitors of molecules involved in cell adhesion may be useful therapeutic agents for the treatment of MPA.
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| Free Research Field |
呼吸器外科
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| Academic Significance and Societal Importance of the Research Achievements |
これまでMPAに係る研究は臨床情報や病理検体を用いることでしか成し得なかったが,我々が樹立した細胞株 (KU-Lu-MPPt3)を用いることで,MPAの分子レベルでの解析が可能となった.MPAの組織学的特徴とKU-Lu-MPPt3細胞株の特徴の類似点から,微小乳頭成分と予後不良の因果関係を探求することで,MPAに対する新規治療法開発にも貢献できる可能性が高く,社会的貢献度が高い.
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