The mechanism of Post operative cognitive disfunction with Anesthesia

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kagoshima University
• Principal Investigator: Mukaihara Keika 鹿児島大学, 医歯学域鹿児島大学病院, 助教 (60837269)
• Co-Investigator(Kenkyū-buntansha): 長谷川 麻衣子 鹿児島大学, 医歯学域医学系, 准教授 (20516637) ; 奥野 浩行 鹿児島大学, 医歯学域医学系, 教授 (80272417)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: オプトジェネティクス / 術後痛

Outline of Final Research Achievements

In the creation of a mouse model of cardiopulmonary arrest, the mice were difficult to resuscitate.
For behavioral changes and immunohistological evaluation after model creation, evaluation was conducted in a mouse model of postoperative pain.It was suggested that the mice develop postoperative cognitive dysfunction after surgery, and the amygdala may be one of the responsible sites. Ischemia-reperfusion injury of organs after resuscitation is said to induce a systemic inflammatory response and cause a systemic inflammatory response syndrome similar to sepsis, which will be investigated in a mouse model of cardiopulmonary arrest using the same experimental techniques as those used in the postoperative pain mice.Translated with www.DeepL.com/Translator (free version)

Free Research Field

麻酔

Academic Significance and Societal Importance of the Research Achievements

手術中は全身麻酔等をおこなうことにより痛みを患者に意識させることはないが、脳の活動は全身麻酔中も痛みを認識しているのかは不明である。また、麻酔を深くし痛みをコントロールすることが良いのか、また深い麻酔は術後の認知機能障害に影響があるのかを検討した。術後痛モデルマウスを作成したが、麻酔の深さによる痛みの変化を捉えることが難しく、更なる研究計画が必要だと考えてる。