2021 Fiscal Year Final Research Report
Investigation of brain protective effects of various pre-conditioning and hypoxia combinations
| Project/Area Number |
19K09369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 低酸素プレコンディショニング / リモートポストコンディショニング / 脳虚血 / 脳梗塞 |
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| Outline of Final Research Achievements |
Cerebral infarct size and IL-6 and IL-1β expression were examined in the control group (without pre- and post-treatment), the hypoxic preconditioning group, the remote post-conditioning group, and the combined hypoxic preconditioning and remote post-conditioning group.
Cerebral infarct size was significantly smaller in the combined hypoxic preconditioning and remote postconditioning group, the hypoxic preconditioning group, and the remote postconditioning group compared to the control group.
IL-6 and IL-1β mRNA expression was significantly lower in the combined hypoxic preconditioning and remote postconditioning group compared to the control group.
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| Free Research Field |
麻酔と脳循環
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| Academic Significance and Societal Importance of the Research Achievements |
低酸素プレコンディショニングとリモートポストコンディショニングにより、脳梗塞形成後のIL-6やIL-1βなどの炎症性サイトカイン発現が抑制される。このことが一因となって、低酸素プレコンディショニングとリモートポストコンディショニングにより、脳梗塞からの脳保護効果が期待できる。
麻酔中に脳梗塞の発症が危惧された場合には、脳以外の遠隔臓器の虚血をつくりだすことにより、脳保護効果が期待できる。
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