2021 Fiscal Year Final Research Report
The development of the novel therapy for the neuropathic pain via pregnancy-induced analgesia
| Project/Area Number |
19K09376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 妊娠鎮痛 / 前帯状皮質 / オピオイド受容体 / ミクログリア |
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| Outline of Final Research Achievements |
Pregnancy-induced analgesia develops in late pregnancy, but its mechanisms are unclear. We demonstrated that pregnancy-induced analgesia ameliorated neuropathic pain by suppressing the activation of microglia in the anterior cingulate cortex in partial sciatic nerve ligation-treated mice. Notably, we also demonstrated that pregnancy produced the upregulation of the δ-opioid receptor in the anterior cingulate cortex. The present results significantly extend our knowledge of the mechanisms of pregnancy-induced analgesia, which could lead to new treatment for neuropathic pain in patients.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
神経障害性疼痛に代表される慢性疼痛は既存の治療法では十分な鎮痛が得られず，新規治療法の確立が急務である．妊娠そのものが慢性疼痛患者の痛みを和らげる事象は“妊娠鎮痛”と呼ばれており，性ホルモン以外の機序が関与することが明らかになっている．本研究の結果から，前帯状皮質のδオピオイド受容体の増加が妊娠鎮痛の機序の一端を担う可能性が示唆された．本研究は，既存の治療法とは全く異なる妊娠鎮痛の機序を介した神経障害性疼痛の新規治療戦略を提案するものであり，神経障害性疼痛患者の痛み治療の開発を発展させるため，社会に果たす意義は大きいと考える．
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