Interactions between inflammation and coagulation by disease type and the significance of vasoactive substances in DIC

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Kanazawa University
• Principal Investigator: Asakura Hidesaku 金沢大学, 附属病院, 准教授 (60192936)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: DIC

Outline of Final Research Achievements

The significance of vasoactive substances was investigated using a rat model of disseminated intravascular coagulation (DIC). Even in the same DIC model, the LPS model showed severe organ damage, but the tissue factor (TF) model showed almost no organ damage. The reason for this is considered to be that the TF model has high fibrinolytic activation (thrombi is easily dissolved) and that the production of nitric oxide (NO), which is a vasodilator, is enhanced. Conventional DIC treatment has mainly been anticoagulant therapy, but there is a possibility that vasodilator regulators will be developed as new therapeutic agents.

Free Research Field

血栓止血学

Academic Significance and Societal Importance of the Research Achievements

DICは、全身臓器に微小血栓が多発して、究極の血栓症とも言える病態である。DICにおける病態解析の手法や、治療法改善の研究は、そのまま一般的な血栓症（脳梗塞、心筋梗塞、いわゆるエコノミークラス症候群など）に対しても応用可能である。ラットなどの動物を用いてDICモデルを作成することは容易であり、今後もDICモデルを用いた研究は、広く血栓症全体に対しても診療レベルの向上につながる可能性が高い。