Molecular biological mechanism of cognitive impairment due to cerebral hyperperfusion after reconstructive surgery

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09534
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Iwate Medical University
• Principal Investigator: Chida Kohei 岩手医科大学, 医学部, 助教 (30611016)
• Co-Investigator(Kenkyū-buntansha): 吉田 研二 岩手医科大学, 医学部, 特任准教授 (10316367)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 脳血行再建術後過灌流 / 認知機能障害

Outline of Final Research Achievements

An optimal rat model representing cerebral hyperperfusion after chronic cerebral ischemia was developed by modifying previous methods. With this ingenious method, severity of chronic cerebral ischemia can be finely controlled, and the intentional arterial stenosis for inducing cerebral hyperperfusion can be easily recovered. We should assess cognitive impairment after cerebral hyperperfusion with this method, analyze the damage of the blood brain barrier and the cerebral parenchyma and then elucidate the mechanism of the cognitive impairment.

Free Research Field

脳循環代謝

Academic Significance and Societal Importance of the Research Achievements

本研究では、既存の手法に改良を加えることで、最適な慢性脳虚血後の過灌流モデルを作成することができた。さらにこのモデルを用いることで、慢性脳虚血後の過灌流により認知機能障害が生じるメカニズムを解明することができる。このメカニズムが解明されることで、本研究が脳血行再建術後過灌流に対する新たな治療法の開発に貢献すると考える。