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2021 Fiscal Year Annual Research Report

Investigation for mechanism of metastasis using molecular imaging

Research Project

Project/Area Number 19K09571
Research InstitutionKanazawa University

Principal Investigator

土屋 弘行  金沢大学, 医学系, 教授 (40227434)

Co-Investigator(Kenkyū-buntansha) 三輪 真嗣  金沢大学, 医学系, 助教 (40753455)
林 克洋  金沢大学, 医薬保健学総合研究科, 特任教授 (80507054)
五十嵐 健太郎  金沢大学, 医薬保健学総合研究科, 特任助教 (80622860)
山本 憲男  金沢大学, 医薬保健学総合研究科, 特任教授 (90332668)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywords骨肉腫 / 転移 / 細胞外小胞 / 破骨細胞
Outline of Annual Research Achievements

【背景】本研究の目的は骨肉腫細胞由来細胞外小胞が破骨細胞の分化に及ぼす影響とその転帰について解明することである.
【方法】易肺転移性のマウス骨肉腫細胞株LM8を使用し,超遠心法にて細胞外小胞を回収,in vitroにて破骨細胞の分化誘導時に添加した.破骨細胞の分化をTRAP染色にて確認し,その分化誘導初期にWestern BlotにてNFκB経路,MAPK経路への影響,誘導2日目に qRT-PCRにて分化誘導に関する分子への影響を調べた.次に細胞外小胞 の排出に関わるTSG101遺伝子をノックアウト(KO)した細胞株を作成し,in vivoにてLM8および TSG101KOLM8をマウスの脛骨内に移植,3-5 週で脛骨および肺を摘出し,組織学的評価を行った.最後に骨肉腫患者の治療前の生検組織の破骨細胞の分化をCathepsin K染色にて評価し,予後との相関を調べた.
【結果】細胞外小胞添加群において10000μm2 以上のTRAP陽性の破骨細胞の数は有意に減少した.qRT-PCRにてTRAPのmRNAおよび,破骨細胞分化の制御分子であるNFATc1とその下流のDC-STAMP,OC-STAMP,Atp6v0dのmRNAはいずれも有意に減少した.NFATc1の上流のNFκB経路でNFκB,IκBαタンパクのリン酸化 の抑制を認めたが,MAPK経路のタンパクのリン酸化の抑制は軽度であった.TSG101-LM8移植マウスはLM8移植マウスに比較し,腫瘍周囲の血管新生と肺転移が有意に抑制された.骨肉腫患者の生検組織で類骨周囲の破骨細胞が陽性症例の全生存率および無転移生存率は有意に良好であった.
【考察】骨肉腫細胞由来細胞外小胞はNFκB経路のタンパクのリン酸化を抑制することで破骨細胞の分化を抑制し,血管新生の促進,肺転移を誘導している可能性が示唆された.今後NFκB経路のリン酸化を抑制する細胞外小胞内の分子を標的とした骨肉腫の新規治療につながる可能性がある.

  • Research Products

    (54 results)

All 2022 2021

All Journal Article (54 results) (of which Peer Reviewed: 54 results,  Open Access: 16 results)

  • [Journal Article] Suture Bridge Fixation for Posterior Cruciate Ligament Tibial Avulsion Fracture in Children2022

    • Author(s)
      Kanayama Tomoyuki、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Arthroscopy Techniques

      Volume: 11 Pages: e609~e613

    • DOI

      10.1016/j.eats.2021.12.012

    • Peer Reviewed
  • [Journal Article] Tibial graft fixation methods and bone tunnel enlargement: A comparison between the TensionLoc implant system and the double-spike plate2022

    • Author(s)
      Kimura Mitsuhiro、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kanayama Tomoyuki、Tsuchiya Hiroyuki
    • Journal Title

      Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology

      Volume: 28 Pages: 31~37

    • DOI

      10.1016/j.asmart.2022.03.003

    • Peer Reviewed
  • [Journal Article] Profunda femoris artery perforator flap for lateral knee joint reconstruction: A report of two cases2022

    • Author(s)
      Tada Kaoru、Matsuta Masashi、Murai Atsuro、Nakamura Yuta、Suganuma Seigo、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 32 Pages: 144~149

    • DOI

      10.1016/j.jpra.2022.02.003

    • Peer Reviewed / Open Access
  • [Journal Article] The Therapeutic Effect and Clinical Outcome of Immune Checkpoint Inhibitors on Bone Metastasis in Advanced Non-Small-Cell Lung Cancer2022

    • Author(s)
      Asano Yohei、Yamamoto Norio、Demura Satoru、Hayashi Katsuhiro、Takeuchi Akihiko、Kato Satoshi、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Yonezawa Hirotaka、Araki Yoshihiro、Morinaga Sei、Saito Shiro、Sone Takashi、Kasahara Kazuo、Tsuchiya Hiroyuki
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: -

    • DOI

      10.3389/fonc.2022.871675

    • Peer Reviewed
  • [Journal Article] Monostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report2022

    • Author(s)
      AZURIN EDELYN S.、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、SAITO SHIRO、TSUCHIYA HIROYUKI
    • Journal Title

      Cancer Diagnosis & Prognosis

      Volume: 2 Pages: 93~100

    • DOI

      10.21873/cdp.10082

    • Peer Reviewed
  • [Journal Article] Iatrogenic sciatic nerve injury due to cerclage wiring for proximal periprosthetic femoral fracture: A rare case report2022

    • Author(s)
      Nakamura Yuta、Tada Kaoru、Murai Atsuro、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 32 Pages: 54~60

    • DOI

      10.1016/j.jpra.2022.02.002

    • Peer Reviewed / Open Access
  • [Journal Article] Deep inferior epigastric artery as a collateral pathway to the lower extremities: A case report2022

    • Author(s)
      Tada Kaoru、Murai Atsuro、Nakamura Yuta、Suganuma Seigo、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 32 Pages: 13~17

    • DOI

      10.1016/j.jpra.2022.01.003

    • Peer Reviewed / Open Access
  • [Journal Article] Management of Soft-tissue Tumors With a Size of 2-5 cm, Including Malignancy2022

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、MAEDA TORU、KIMURA HIROAKI、OTA TAKASHI、SHIMOZAKI SHINGO、KATO TAKASHI、INOUE DAISUKE、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Pages: 1555~1562

    • DOI

      10.21873/anticanres.15629

    • Peer Reviewed
  • [Journal Article] Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma2022

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Pages: 1096~1096

    • DOI

      10.3390/ijms23031096

    • Peer Reviewed
  • [Journal Article] Equinus foot deformity and malunion of the medial malleolus caused by tibialis posterior tendon interposition following irreducible fracture dislocation of the ankle: A case report and literature review2022

    • Author(s)
      Hikichi Toshifumi、Matsubara Hidenori、Shimokawa Kanu、Watanabe Koji、Tsuchiya Hiroyuki
    • Journal Title

      Trauma Case Reports

      Volume: 38 Pages: 100618~100618

    • DOI

      10.1016/j.tcr.2022.100618

    • Peer Reviewed
  • [Journal Article] Pretreatment Neutrophil Count and Platelet-lymphocyte Ratio as Predictors of Metastasis in Patients With Osteosarcoma2022

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Pages: 1081~1089

    • DOI

      10.21873/anticanres.15570

    • Peer Reviewed
  • [Journal Article] Anterior cruciate ligament reconstruction with ultrasound-guided femoral nerve block does not adversely affect knee extensor strength beyond that seen with intravenous patient-controlled analgesia at 3 and 6?months postoperatively2022

    • Author(s)
      Sengoku Takuya、Nakase Junsuke、Morita Yui、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Sakurai Goro、Yoshida Shinya、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      The Knee

      Volume: 34 Pages: 252~258

    • DOI

      10.1016/j.knee.2022.01.006

    • Peer Reviewed
  • [Journal Article] Does Dosage or Duration of Concurrent Oral Corticosteroid Influence Elevated Risk of Postoperative Complications After Total Joint Arthroplasty?2022

    • Author(s)
      Inoue Daisuke、Kabata Tamon、Kajino Yoshitomo、Ohmori Takaaki、Yamamuro Yuki、Taninaka Atsushi、Kataoka Tomoyuki、Saiki Yoshitomo、Tsuchiya Hiroyuki
    • Journal Title

      The Journal of Arthroplasty

      Volume: 37 Pages: 652~658

    • DOI

      10.1016/j.arth.2021.12.032

    • Peer Reviewed
  • [Journal Article] Differences in cellular and microstructural properties of the semitendinosus muscle tendon between young and adult patients2022

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Ishikawa Tatsuya、Yoshimizu Rikuto、Kimura Mitsuhiro、Ozaki Noriyuki、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 27 Pages: 478~485

    • DOI

      10.1016/j.jos.2021.01.012

    • Peer Reviewed
  • [Journal Article] Safety and Neurologic Recovery of L2 Nerve Root Sacrificed in Total En Bloc Spondylectomy Involving the L2 Vertebra2021

    • Author(s)
      Paholpak Permsak、Sangsin Apiruk、Sirichativapee Winai、Wisanuyotin Taweechok、Kosuwon Weerachai、Kasai Yuichi、Murakami Hideki、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Spine Surgery

      Volume: 15 Pages: 1217~1222

    • DOI

      10.14444/8154

    • Peer Reviewed
  • [Journal Article] Anaphylactic Reactions Caused by Nafamostat Mesylate during Hemodialysis before Surgery for Carpal Tunnel Syndrome2021

    • Author(s)
      Nakamura Yuta、Tada Kaoru、Matsuta Masashi、Murai Atsuro、Tsuchiya Hiroyuki
    • Journal Title

      Case Reports in Nephrology

      Volume: 2021 Pages: 1~4

    • DOI

      10.1155/2021/1148156

    • Peer Reviewed
  • [Journal Article] Impact of Tumor Growth Speed of Primary Lesions on the Clinical Outcomes of Appendicular Skeletal Metastases2021

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、SAITO SHIRO、NOJIMA TAKAYUKI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Pages: 229~236

    • DOI

      10.21873/anticanres.15477

    • Peer Reviewed
  • [Journal Article] Insufficient Augmentation of Bone Cement Causes Recompression of Augmented Vertebra after Balloon Kyphoplasty2021

    • Author(s)
      Kobayashi Motoya、Toribatake Yasumitsu、Okamoto Shunpei、Kato Satoshi、Tsuchiya Hiroyuki
    • Journal Title

      Spine Surgery and Related Research

      Volume: 5 Pages: 375~380

    • DOI

      10.22603/ssrr.2020-0019

    • Peer Reviewed
  • [Journal Article] The prevalence and impact of sarcopenia in females undergoing total hip arthroplasty: A prospective study2021

    • Author(s)
      Ueoka Ken、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Ohmori Takaaki、Ueno Takuro、Yoshitani Junya、Yamamuro Yuki、Taninaka Atsushi、Kato Satoshi、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      Modern Rheumatology

      Volume: 32 Pages: 193~198

    • DOI

      10.1080/14397595.2021.1899603

    • Peer Reviewed
  • [Journal Article] Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation2021

    • Author(s)
      Kimura Hiroaki、Yamamoto Norio、Hayashi Katsuhiro、Higuchi Takashi、Tsuchiya Hiroyuki
    • Journal Title

      Case Reports in Oncology

      Volume: 14 Pages: 1490~1496

    • DOI

      10.1159/000519212

    • Peer Reviewed
  • [Journal Article] Clinical characteristics of patients with undergoing unplanned excisions of malignant soft tissue tumors2021

    • Author(s)
      Morinaga Sei、Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Langit Mickhael B、Yonezawa Hirotaka、Araki Yoshihiro、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29 Pages: -

    • DOI

      10.1177/23094990211057597

    • Peer Reviewed
  • [Journal Article] Does remnant tissue preservation in anterior cruciate ligament reconstruction influence the creation of the rectangular femoral tunnel?2021

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29 Pages: -

    • DOI

      10.1177/23094990211061249

    • Peer Reviewed
  • [Journal Article] Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review2021

    • Author(s)
      HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 41 Pages: 5865~5871

    • DOI

      10.21873/anticanres.15406

    • Peer Reviewed
  • [Journal Article] Accuracy of different navigation systems for femoral and tibial implantation in total knee arthroplasty: a randomised comparative study2021

    • Author(s)
      Saiki Yoshitomo、Ojima Tomohiro、Kabata Tamon、Hayashi Seigaku、Tsuchiya Hiroyuki
    • Journal Title

      Archives of Orthopaedic and Trauma Surgery

      Volume: 141 Pages: 2267~2276

    • DOI

      10.1007/s00402-021-04205-3

    • Peer Reviewed
  • [Journal Article] Usefulness of ultrasonography for dynamic evaluation of medial meniscus hoop function in early knee osteoarthritis2021

    • Author(s)
      Shimozaki Kengo、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Kanayama Tomoyuki、Kitagawa Takashi、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: -

    • DOI

      10.1038/s41598-021-99576-3

    • Peer Reviewed / Open Access
  • [Journal Article] Skeletally immature patient showed lower graft maturity than skeletally mature patient after ACL reconstruction with a rounded rectangular femoral tunnel2021

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Shimozaki Kengo、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: -

    • DOI

      10.1038/s41598-021-99532-1

    • Peer Reviewed / Open Access
  • [Journal Article] Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report2021

    • Author(s)
      Suganuma Seigo、Tada Kaoru、Yamauchi Daisuke、Takagawa Shingo、Yasutake Hidetoshi、Shimanuki Keito、Minato Hiroshi、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 30 Pages: 91~96

    • DOI

      10.1016/j.jpra.2021.08.001

    • Peer Reviewed / Open Access
  • [Journal Article] Rat model of an autologous cancellous bone graft2021

    • Author(s)
      Hamada Tomo、Matsubara Hidenori、Hikichi Toshifumi、Shimokawa Kanu、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: -

    • DOI

      10.1038/s41598-021-97573-0

    • Peer Reviewed / Open Access
  • [Journal Article] Current Management of Bone Metastases from Differentiated Thyroid Cancer2021

    • Author(s)
      Kato Satoshi、Demura Satoru、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Pages: 4429~4429

    • DOI

      10.3390/cancers13174429

    • Peer Reviewed / Open Access
  • [Journal Article] The influence of pelvic tilt on stress distribution in the acetabulum: finite element analysis2021

    • Author(s)
      Hasegawa Kazuhiro、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Sakamoto Jiro、Tsuchiya Hiroyuki
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 22 Pages: -

    • DOI

      10.1186/s12891-021-04500-5

    • Peer Reviewed / Open Access
  • [Journal Article] Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib2021

    • Author(s)
      HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 18 Pages: 637~643

    • DOI

      10.21873/cgp.20286

    • Peer Reviewed
  • [Journal Article] Intrathecal baclofen therapy for severe spasticity in an adult with tethered cord syndrome: a case report2021

    • Author(s)
      Takagi Yasutaka、Yamada Hiroshi、Ebara Hidehumi、Hayashi Hiroyuki、Kidani Satoshi、Toyooka Kazu、Ishino Yuji、Kitano Yoshiyuki、Nakanami Aki、Kagechika Kenji、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Medical Case Reports

      Volume: 15 Pages: -

    • DOI

      10.1186/s13256-021-03049-0

    • Peer Reviewed
  • [Journal Article] Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults2021

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: -

    • DOI

      10.1038/s41598-021-96162-5

    • Peer Reviewed / Open Access
  • [Journal Article] Distal Radius Fracture with Bone Fragment Protruded into the Radiocarpal Joint: Two Case Reports2021

    • Author(s)
      Tada Kaoru、Ikeda Kazuo、Tsuchiya Hiroyuki
    • Journal Title

      The Journal of Hand Surgery (Asian-Pacific Volume)

      Volume: 26 Pages: 460~462

    • DOI

      10.1142/S2424835521720164

    • Peer Reviewed
  • [Journal Article] Vertebra-Pediculoplasty: A New Approach to Treatment of Split-Type and Delayed-Union Osteoporotic Vertebral Fracture with a Risk of Cement Dislodgement2021

    • Author(s)
      Yonezawa Noritaka、Yonezawa Yoshiro、Nishimura Tatsuya、Yamashiro Teruhisa、Shimozaki Kengo、Mori Akari、Demura Satoru、Tsuchiya Hiroyuki
    • Journal Title

      World Neurosurgery

      Volume: 155 Pages: e55~e63

    • DOI

      10.1016/j.wneu.2021.07.142

    • Peer Reviewed
  • [Journal Article] Patient-reported Outcome and Quality of Life after Treatment with External Fixation: A Questionnaire-based Survey2021

    • Author(s)
      Tsuchiya Hiroyuki、Ugaji Shuhei、Matsubara Hidenori、Kato Satoshi、Yoshida Yasuhisa、Hamada Tomo
    • Journal Title

      Strategies in Trauma and Limb Reconstruction

      Volume: 16 Pages: 27~31

    • DOI

      10.5005/jp-journals-10080-1519

    • Peer Reviewed
  • [Journal Article] A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma2021

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Yonezawa Hirotaka、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Saito Shiro、Okuda Miho、Taki Junichi、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Pages: 3558~3558

    • DOI

      10.3390/cancers13143558

    • Peer Reviewed / Open Access
  • [Journal Article] Excessive anterior tibial translation in the contralateral uninjured limb is significantly associated with ramp lesion in anterior cruciate ligament injury2021

    • Author(s)
      Asai Kazuki、Nakase Junsuke、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Experimental Orthopaedics

      Volume: 8 Pages: -

    • DOI

      10.1186/s40634-021-00372-9

    • Peer Reviewed
  • [Journal Article] How to Detect Meniscal Ramp Lesions Using?Ultrasound2021

    • Author(s)
      Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Kimura Mitsuhiro、Tsuchiya Hiroyuki
    • Journal Title

      Arthroscopy Techniques

      Volume: 10 Pages: e1539~e1542

    • DOI

      10.1016/j.eats.2021.02.022

    • Peer Reviewed
  • [Journal Article] Efficacy of perioperative chemotherapy for synovial sarcoma: a retrospective analysis of a Nationwide database in Japan2021

    • Author(s)
      Xu Gang、Aiba Hisaki、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Araki Yoshihiro、Saito Shiro、Yoshimura Kenichi、Murakami Hideki、Tsuchiya Hiroyuki、Kawai Akira
    • Journal Title

      BMC Cancer

      Volume: 21 Pages: -

    • DOI

      10.1186/s12885-021-08485-1

    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between lag screw route and the ideal insertion point of the intramedullary nail2021

    • Author(s)
      Yoshitani Junya、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Ohmori Takaaki、Ueoka Ken、Yamamuro Yuki、Taninaka Atsushi、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: -

    • DOI

      10.1038/s41598-021-93348-9

    • Peer Reviewed / Open Access
  • [Journal Article] Delayed Initiation of Treatment Is Associated With Metastasis of Malignant Bone Tumor2021

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Pages: 2993~2999

    • DOI

      10.21873/anticanres.15081

    • Peer Reviewed
  • [Journal Article] Surgical Metastasectomy in the Spine: A Review Article2021

    • Author(s)
      Kato Satoshi、Demura Satoru、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Murakami Hideki、Kawahara Norio、Tomita Katsuro、Tsuchiya Hiroyuki
    • Journal Title

      The Oncologist

      Volume: 26 Pages: e1833~e1843

    • DOI

      10.1002/onco.13840

    • Peer Reviewed
  • [Journal Article] Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p2021

    • Author(s)
      Araki Yoshihiro、Aiba Hisaki、Yoshida Takeshi、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Nguyen Tuan D.、Ishii Kiyo-aki、Nojima Takayuki、Takahashi Satoru、Murakami Hideki、Tsuchiya Hiroyuki、Hanayama Rikinari
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: -

    • DOI

      10.3389/fonc.2021.667109

    • Peer Reviewed
  • [Journal Article] Change in leg length after open-wedge high tibial osteotomy can be predicted from the opening width: A three-dimensional analysis2021

    • Author(s)
      Yamamuro Yuki、Kabata Tamon、Goshima Kenichi、Kajino Yoshitomo、Inoue Daisuke、Ohmori Takaaki、Ueno Takuro、Takagi Tomoharu、Yoshitani Junya、Ueoka Ken、Taninaka Atsushi、Tsuchiya Hiroyuki
    • Journal Title

      The Knee

      Volume: 30 Pages: 185~194

    • DOI

      10.1016/j.knee.2021.04.010

    • Peer Reviewed
  • [Journal Article] Perioperative complications of total en bloc spondylectomy for spinal tumours2021

    • Author(s)
      Demura Satoru、Kato Satoshi、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Handa Makoto、Annen Ryohei、Kobayashi Motoya、Yamada Yohei、Murakami Hideki、Kawahara Norio、Tomita Katsuro、Tsuchiya Hiroyuki
    • Journal Title

      The Bone & Joint Journal

      Volume: 103-B Pages: 976~983

    • DOI

      10.1302/0301-620X.103B5.BJJ-2020-1777.R1

    • Peer Reviewed
  • [Journal Article] Bone and Soft Tissue Tumors: New Treatment Approaches2021

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Pages: 1832~1832

    • DOI

      10.3390/cancers13081832

    • Peer Reviewed / Open Access
  • [Journal Article] Total en bloc spondylectomy is worth doing in complete paralysis spinal giant cell tumor, a minimum 1-year follow-up2021

    • Author(s)
      Paholpak Permsak、Sangsin Apiruk、Sirichativapee Winai、Wisanuyotin Taweechok、Kosuwon Weerachai、Sumnanoont Chat、Thammaroj Puntip、Ungarreevittaya Piti、Kasai Yuichi、Murakami Hideki、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29 Pages: -

    • DOI

      10.1177/23094990211005900

    • Peer Reviewed
  • [Journal Article] Antibacterial Activity in Iodine-coated Implants Under Conditions of Iodine Loss: Study in a Rat Model Plus In Vitro Analysis2021

    • Author(s)
      Ueoka Ken、Kabata Tamon、Tokoro Masaharu、Kajino Yoshitomo、Inoue Daisuke、Takagi Tomoharu、Ohmori Takaaki、Yoshitani Junya、Ueno Takuro、Yamamuro Yuki、Taninaka Atsushi、Tsuchiya Hiroyuki
    • Journal Title

      Clinical Orthopaedics & Related Research

      Volume: 479 Pages: 1613~1623

    • DOI

      10.1097/CORR.0000000000001753

    • Peer Reviewed
  • [Journal Article] The effect of gracilis tendon harvesting in addition to semitendinosus tendon harvesting on knee extensor and flexor strength after anterior cruciate ligament reconstruction2021

    • Author(s)
      Sengoku Takuya、Nakase Junsuke、Asai Kazuki、Yoshimizu Rikuto、Sakurai Goro、Yoshida Shinya、Yahata Tetsutaro、Tsuchiya Hiroyuki
    • Journal Title

      Archives of Orthopaedic and Trauma Surgery

      Volume: 142 Pages: 465~470

    • DOI

      10.1007/s00402-021-03877-1

    • Peer Reviewed
  • [Journal Article] Complete Response of Bone Metastasis in Non-small Cell Lung Cancer With Pembrolizumab: Two Case Reports2021

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、KASAHARA KAZUO、SONE TAKASHI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Pages: 1693~1699

    • DOI

      10.21873/anticanres.14933

    • Peer Reviewed
  • [Journal Article] Spontaneous extensor tendon rupture due to scaphoid osteophyte: A case report and literature review2021

    • Author(s)
      Suganuma Seigo、Tada Kaoru、Takagawa Shingo、Yasutake Hidetoshi、Shimanuki Keito、Tsuchiya Hiroyuki
    • Journal Title

      JPRAS Open

      Volume: 28 Pages: 66~71

    • DOI

      10.1016/j.jpra.2021.02.006

    • Peer Reviewed / Open Access
  • [Journal Article] Clinical outcomes and prognostic factors following the surgical resection of renal cell carcinoma spinal metastases2021

    • Author(s)
      Kato Satoshi、Demura Satoru、Murakami Hideki、Yoshioka Katsuhito、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Kawahara Norio、Tsuchiya Hiroyuki
    • Journal Title

      Cancer Science

      Volume: 112 Pages: 2416~2425

    • DOI

      10.1111/cas.14902

    • Peer Reviewed / Open Access
  • [Journal Article] Contralateral Lower-Limb Functional Status Before Total Hip Arthroplasty2021

    • Author(s)
      Ohmori Takaaki、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Kato Satoshi、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Bone and Joint Surgery

      Volume: 103 Pages: 1093~1103

    • DOI

      10.2106/JBJS.20.00949

    • Peer Reviewed

URL: 

Published: 2022-12-28  

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