Fracture treatment intervention targeting Wnt10a

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: wang keyong 産業医科大学, 教育研究支援施設, 准教授 (30369053)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 骨折 / 骨再生 / 線維芽細胞 / Wnt10a / 創傷治癒

Outline of Final Research Achievements

Purpose of the study: The treatment of intractable fractures with extensive skin defects is a very difficult problem in the orthopedic field. In this study, we try to clarify the role of Wnt10a in the fracture healing process using the Wnt10a gene-deficient mouse developed by the researcher, and also to examine a way to solve both of the skin tissue wound and the fracture healing problem at the same time.
Research Results: Wnt10a has been suggested to play an important role in wound skin regeneration, periosteal repair and callus formation. Especially in the early stage of the fracture healing process, the proliferation of fibroblasts at the skin defect site and around the periosteum were promoted, and the expression of Wnt10a was significantly enhanced by the addition of BMP-2 (bone morphogenetic protein).

Free Research Field

実験病理学

Academic Significance and Societal Importance of the Research Achievements

この研究から、Wnt10a は線維芽細胞の増殖因子であり、主に骨膜の修復や骨膜性仮骨の形成において重要な役割を担っていることが証明された。Wnt10aの研究おいて、我々は全世界をリードして研究を進めており、Wnt10aを標的とした新しい創傷・骨折治療薬の開発も将来的に考えている。難治性骨折患者の機能予後改善・早期社会復帰を目指ざす上で、Wnt10aを標的とした本研究成果は重大な一歩となり得る。