2021 Fiscal Year Final Research Report

Cartilage repair covered with autologous fibrin sheet on microfracture

Research Project

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Project/Area Number	19K09654
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56020:Orthopedics-related
Research Institution	Osaka City University
Principal Investigator	Minoda Yukihide 大阪市立大学, 大学院医学研究科, 講師 (90453133)
Co-Investigator(Kenkyū-buntansha)	橋本祐介大阪市立大学, 大学院医学研究科, 講師 (10382178) 折田久美大阪市立大学, 大学院医学研究科, 博士研究員 (40748597) 佐伯壮一名城大学, 理工学部, 教授 (50335767)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	Platelet-Rich Fibrin / 軟骨修復 / ウサギ
Outline of Final Research Achievements	Purpose of this study is to determine the in vivo effectiveness of a single-stage surgical procedure that combines microfracture and an autologous platelet-rich fibrin (PRF) membrane for cartilage repair in a rabbit model. Cartilage defects were created in the trochlear groove of the knees of adult white rabbits. Defects were divided into 2 treatment groups: microfracture only (control group) and microfracture covered by a PRF membrane (PRF group). The ICRS macroscopic scores and modified Wakitani scores showed that a single-stage surgical procedure combining microfracture and a PRF membrane was more effective than surgery with only microfracture for promoting cartilage repair. Clinical relevance: A single-stage surgical procedure combining microfracture and an autologous PRF membrane is a potentially beneficial treatment method for cartilage defects that does not require using any xenocollagen membrane.
Free Research Field	運動器
Academic Significance and Societal Importance of the Research Achievements	軟骨は血流に乏しいため損傷をきたすと治りにくい組織である。しかし損傷して軟骨本来の衝撃吸収機能を失うと、関節軟骨に負荷がかかることから変形性関節症に至り、将来の膝関節痛の原因となる。その治癒能の乏しさから治療成績に限界があるのが現状である。今回は多血小板血漿フィブリンシートとマイクロフラクチャーを組み合わせた一期的手術方法によって、軟骨の良好な修復が得られることが確認できた。これは臨床に応用すれば、軟骨損傷の治療成績の向上に役立てられる可能性がある。