Research for elucidating the relationship between inversion of the acetabular labrum and subchondral fracture of the femoral head (bone marrow edema) in rapidly progressive osteoarthritis of the hip

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09657
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: FUKUI Kiyokazu 金沢医科大学, 医学部, 准教授 (00440503)
• Co-Investigator(Kenkyū-buntansha): 兼氏 歩 金沢医科大学, 医学部, 教授 (00303305)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 急速破壊型股関節症 / 急速進行性股関節症 / 内反関節唇 / 大腿骨頭軟骨下骨折 / 骨粗鬆症 / 疲労骨折

Outline of Final Research Achievements

Several studies have reported that subchondral fragility fractures of the femoral head are involved in rapidly progressive hip joint disease. The mode of occurrence of fractures is unknown, whether it is a subchondral fracture caused by a single load caused by trauma such as a fall, or a stress fracture (fragile fracture) caused by repeated loading associated with walking in daily life without obvious episodes such as trauma. The purpose of this study was to examine whether the femoral head subchondral fragile fracture occurs due to the intervention of the varus labrum when the simulated bone of the osteoporosis model is repeatedly loaded.
In this study, in the osteoporosis model simulated bone, when a load is repeatedly applied assuming daily life movement, a rubber piece simulating the varus acetabular labrum may cause a subchondral fragility fracture of the femoral head. It became clear.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、近年本邦において増加傾向にある大腿骨頭軟骨下脆弱性骨折の原因を明らかにするものであり、今後人工股関節によらない治療法の確立に繋がる重要な成果と考える。