Clinical application of photodynamic therapy using HPMA-ZnPP for gynecologic cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Kagoshima University
• Principal Investigator: Shintaro Yanazume 鹿児島大学, 医歯学域鹿児島大学病院, 講師 (40623343)
• Co-Investigator(Kenkyū-buntansha): 方 軍 崇城大学, 薬学部, 准教授 (20412736)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: HPMA / ZnPP / EPR効果 / PDT / ドラッグデリバリーシステム / ナノメディシン

Outline of Final Research Achievements

The effect of photodynamic therapy (PDT) on HPMA-ZnPP, which is a combination of zinc protoporphyrin (ZnPP) and the biocompatible polymer polymer hydroxypropyl metaacrylamide (HPMA)in gynecologic malignancies were investigated. Tumor models including resistant recurrent ovarian cancer cell line, uterine sarcoma, Hela which has implanted in the nude mice dorsal skin were established. After setting conditions such as the amount of light, wavelength, and irradiation range of the light source irradiation device, the antitumor effect of HPMA-ZnPP on tumors is higher than that of ZnPP in vivo. The cytotoxicity effect of light irradiation was confirmed as the amount of irradiation doses increased.

Free Research Field

婦人科腫瘍

Academic Significance and Societal Importance of the Research Achievements

HPMA-ZnPPは従来のPDTの抗がん効果を腫瘍特異的に大幅に増強し、従来の抗がん治療で難治性であった進行婦人科がん特に子宮頸癌への効果が期待できる。正常組織では認めないが癌病巣・癌細胞には顕著な効果を示すことから、周囲臓器への影響が少なく副作用が少なくこの試みは交叉耐性を有する進行例を含めた固形がん治療に貢献する可能性がある。