Pathophysiolosy of insulin resistance in pregnancy in terms of the inter-organ networks

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Ehime University
• Principal Investigator: SUGIYAMA TAKASHI 愛媛大学, 医学系研究科, 教授 (10263005)
• Co-Investigator(Kenkyū-buntansha): 内倉 友香 愛媛大学, 医学系研究科, 助教 (50648623) ; 松原 裕子 愛媛大学, 医学部附属病院, 講師 (60403820) ; 高木 香津子 愛媛大学, 医学部附属病院, 助教 (80648626)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 妊娠 / 子宮内環境 / マウス / DOHaD / 食餌介入 / 肥満 / 高脂肪食

Outline of Final Research Achievements

The long-term effect of changes in maternal dietary composition during pregnancy on the offspring's metabolic homeostasis is uncertain. We aimed to
investigate the long-term effects of maternal balanced low-fat interventions on metabolic homeostasis of the offspring using a mouse model of gestational
obesity induced by a high-fat diet (HFD). Changes in the intervention diet improved glucose tolerance in pups at 3 and 12 weeks of age. We also performed transcriptomic analysis of the liver in neonatal and 3-week-old pups. Genes in the peroxisome proliferator-activated receptor signaling pathway were significantly down-regulated in neonates in the intervention group compared with the HFD group. The interventio diet compensated for the detrimental effects of a maternal HFD on glucose and lipid metabolism in male offspring by changing the gene expression profile. These data suggest that maternal balanced low-fat intervention is critical for improving the metabolic health of offsprings.

Free Research Field

DOHaD、周産期医学、栄養・代謝・内分泌学

Academic Significance and Societal Importance of the Research Achievements

肥満女性に対する妊娠中の食事介入が母体のみならず次世代に好影響を及ぼすことをマウスモデルを用いてエピジェネティックなメカニズムとともに明らかにすることができた。
今後、本モデルマウスを用いて予防や治療に関するさらなる方策を探ることができる点で学術的および社会的意義を有すると考えられた。