Mechanisms of cancer cell proliferation in hypopharyngeal cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K09903
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Matsuura Kazuto 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 共同研究員 (70271947)
• Co-Investigator(Kenkyū-buntansha): 望月 麻衣 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 研究員 (40726303) ; 浅田 行紀 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (70436103)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 下咽頭がん

Outline of Final Research Achievements

We found that the proliferation of hypopharyngeal cancer is almost complete dependent on a molecule X. Knockdown of Molecule X causes cancer cells to arrest proliferation, but the molecular mechanism for this is not clear. Recently, we obtained preliminary experimental results showing that signals from the Molecular X protein do not affect cancer cell proliferation and that Molecular X mRNA is an essential factor. In this project, we will elucidate a largely unknown area in which mRNA regulates cancer cell proliferation signals. This will not only identify new therapeutic targets for hypopharyngeal cancer, but also reveal new aspects of cancer growth signaling.

Free Research Field

頭頸部外科

Academic Significance and Societal Importance of the Research Achievements

私たちは下咽頭がんにおける新たな治療標的分子Xを同定した。今後も治療応用に向けてさらにデータを蓄積する必要がある。