2021 Fiscal Year Final Research Report
Examination of drug repositioning in retinal degenerative diseases
Project/Area Number |
19K09960
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 56060:Ophthalmology-related
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
Kohno Hideo 東京慈恵会医科大学, 医学部, 講師 (60514536)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 網膜変性 / 炎症 / ドラッグリポジショニング / マイクログリア |
Outline of Final Research Achievements |
We used microglia / macrophage visualized retinal degeneration spontaneous onset model Mertk-/-Cx3cr1GFP / + Ccr2RFP / + mice, to assess drug repositioning. Lecithin-Bound Iodine or minocycline were administrated Mertk-/-Cx3cr1GFP / + Ccr2RFP / + mice. As a result, retinal degeneration was alleviated by administration of lecithin-bound iodine, and the maintenance of retinal function was confirmed by electroretinogram. Administration of minocycline also alleviated retinal degeneration. These drugs are considered to be drugs that can be expected to have a therapeutic effect even in patients with retinal degeneration.
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Free Research Field |
眼科学
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Academic Significance and Societal Importance of the Research Achievements |
加齢黄斑変性や網膜色素変性(Retinitis pigmentosa; RP)などの網膜変性疾患は視細胞死を生じ失明に直結する難治性疾患である。現在、これらの変性疾患において様々な治療法の開発が行われているが、当研究においても網膜変性疾患における新たな治療アプローチの方法論を示すことができ、社会学的、学術的意義が高いと考えられる。
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