2021 Fiscal Year Final Research Report
Analysis of oral bacterialflora and disease-related genes in the pathogenesis of Behcet's disease
| Project/Area Number |
19K09975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
南場 研一 北海道大学, 大学病院, 講師 (70333599)
長澤 敏行 北海道医療大学, 歯学部, 教授 (90262203)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ベーチェット病 / 口腔細菌叢 / フローラ / ユーラシア大陸 |
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| Outline of Final Research Achievements |
We reported 2 original papers in English on the characteristics of the clinical features of Behcet's disease in Mongolia and on the characteristics of the oral microflora. The clinical features of Behcet's disease in Mongolia were not significantly different from those in other countries, but ulcers on the nasal mucosa were more common, and further investigation is needed to determine whether this is a common feature of the disease in the Central Asian region. In the oral flora, the genus Akkermansia was decreased.
In Jordan, due to the spread of new coronavirus infection, hair samples were collected and DNA was extracted as an alternative, and HLA typing is being conducted in advance.
In Japanese, autoantibodies associated with autoimmune diseases were specifically detected in blood samples from patients with Behcet's disease.
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| Free Research Field |
眼科学
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| Academic Significance and Societal Importance of the Research Achievements |
ベーチェット病多発地域はなぜシルクロード地域に偏在しているのか、臨床像は同一なのか、という問いに挑んだ。
地域性の理由の一つは遺伝要因であることはわかっているが、環境要因について日本とユーラシア大陸の国で調査したところ、口腔内細菌叢である菌種の減少が見られた。世界初の成果であるが、他の国でも同様の結果が出るのか更なる検討が必要。臨床像は各国ほぼ類似していたが、モンゴルでは鼻粘膜潰瘍が多くみられた。日本ではほとんど見られない症状のため。こちらも引き続き検討が必要。
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