2023 Fiscal Year Final Research Report
Role of extracellular acidity on tumor heterogeneity
| Project/Area Number |
19K10074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57020:Oral pathobiological science-related
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
前田 豊信 奥羽大学, 歯学部, 教授 (10382756)
鈴木 厚子 奥羽大学, 歯学部, 講師 (90405986)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 酸性環境 |
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| Outline of Final Research Achievements |
The extracellular environment in cancer tissues is well known to be acidic, a phenomenon known as aerobic glycolysis or the Warburg effect. However, understanding of the impact of acidic extracellular pH on tumor heterogeneity is limited. We sought to clarify whether the acidic extracellular environment generated by cancer cells themselves feeds back on the cancer cells themselves and contributes to heterogeneity within cancer tissues. The results showed that cancer cell characteristics are significantly affected by the strength and exposure time of the acidic extracellular pH, contributing to the heterogeneity of cancer tissues.
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| Free Research Field |
がんの転移
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| Academic Significance and Societal Importance of the Research Achievements |
がん細胞の悪性化メカニズムにがん細胞自身が形成する酸性環境が重要な環境因子として働き、その酸度や曝露時間によりがん細胞の形質が変化することが明らかとなり、がん組織の不均一性を誘導することに寄与していること、この形質変化は、ある特定のがんの種類というよりはむしろ普遍性があるということ、そしてその普遍性は、がんのアルカリ化療法の有用性を理解する根拠となり得ることが提示でき、今後のがん治療に貢献できるものと考えられる。
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