Construction of low invasive therapy for alveolar bone regeneration in clinical use

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Taisei Gakuin University
• Principal Investigator: Ohura Kiyoshi 太成学院大学, 看護学部, 教授 (20131378)
• Co-Investigator(Kenkyū-buntansha): 山本 まりこ (河井まりこ) 関西女子短期大学, その他部局等, 教授 (40379839)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 歯槽骨 / 再生

Outline of Final Research Achievements

The research was conducted with the aim of developing a safe and minimally invasive alveolar bone regeneration therapy as a new treatment system for alveolar bone regeneration, which currently relies solely on surgical treatment. Specifically, the following goals were set to promote alveolar bone regeneration by safely and efficiently applying Bone Morphogenetic Protein (BMP) a cytokine known for its strong potential to induce bone to the periodontal tissues. This is because once alveolar bone is lost, it cannot regenerate naturally. We tried to establish an alveolar bone regeneration therapy by applying the BMP gene expression system combining a non-viral BMP expression vector with in vivo electroporation to the periodontal tissues. Second, we tried to analyze the local and systemic effects by BMP gene transfer to the periodontal tissues in order to establish safety.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

歯周病が単なる加齢現象でなく、歯周病菌による炎症という病態が明らかになったものの、その治療法は十分ではない。それ故、本研究によって、外科的処置を伴わない歯槽骨再生治療が開発されることは歯科医療における革新と発展へ大きく寄与する可能性がある。また、本研究による低侵襲性骨再生法は歯槽骨といった口腔領域に関わらず、整形外科領域での骨再建法や骨折治療への応用が可能である。