The active challenge for caries prevention by titanium compounds

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Asahi University
• Principal Investigator: Okuyama Katsushi 朝日大学, 歯学部, 准教授 (00322818)
• Co-Investigator(Kenkyū-buntansha): 松田 康裕 北海道医療大学, 歯学部, 准教授 (50431317) ; 玉置 幸道 朝日大学, 歯学部, 教授 (80197566)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: フッ化チタン / う蝕抑制 / グラスアイオノマーセメント

Outline of Final Research Achievements

The study aims to develop a wide range of applications of titanium fluoride in dentistry, which is not widely used in Japan. The purpose of this study was 1) to estimate the effective concentration and pH of titanium fluoride for topical application to tooth structure and 2) to evaluate the effects of adding titanium fluoride to glass ionomer cement.
The results of this study showed that 0.5% titanium fluoride solution may be the lowest concentration for caries prevention, and there was no significant difference between slightly acidic to neutral solutions. Titanium fluoride appeared to be more effective than sodium fluoride for caries prevention at the same fluoride concentration and pH. The addition of glass ionomer cement increased the caries-preventive effect compared with the original cement, but did not improve the mechanical properties.

Free Research Field

歯科保存学、歯科材料学

Academic Significance and Societal Importance of the Research Achievements

歯科において様々なフッ化物が使用されているが、日本では余り使用されていないフッ化チタンの可能性に着目し、う蝕予防効果などを検討した。他の用途で高濃度の溶液が用いられているが、口腔内での使用を目指し低濃度における効果を検討し、濃度を提示することができた。また既存の材料に添加することで、さらなるう蝕抑制効果の促進が示唆された。これらの結果から、今後のう蝕予防の方法の一つとして提案できるものと思われる。