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2022 Fiscal Year Final Research Report

Interaction between M2 macrophages and Schwann cells during wound healing in human dental pulp

Research Project

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Project/Area Number 19K10146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionNiigata University

Principal Investigator

Yoshiba Nagako  新潟大学, 医歯学総合病院, 講師 (10323974)

Co-Investigator(Kenkyū-buntansha) 吉羽 邦彦  新潟大学, 医歯学系, 教授 (30220718)
大倉 直人  新潟大学, 医歯学総合病院, 助教 (00547573)
枝並 直樹  新潟大学, 医歯学系, 助教 (80804567)
Project Period (FY) 2019-04-01 – 2023-03-31
Keywordsヒト歯髄 / 創傷治癒 / マクロファージ / シュワン細胞 / ラミニン / リンパ管
Outline of Final Research Achievements

Macrophages, which play a central role in immune function, are known to have two types with different functional properties. One is called M1 type, which promotes inflammation, and the other is called M2 type, which suppresses inflammation and works for tissue repair. In this study, we analyzed the dynamics of macrophages, especially the M2 type macrophages, in human dental pulp and found that Schwann cells are greatly involved in the induction of the M2 type macrophages.

Free Research Field

保存治療系歯学

Academic Significance and Societal Importance of the Research Achievements

ヒト歯髄組織を用い,小動物とは異なるマクロファージの動態の解明に繋がった。CD163陽性M2型マクロファーは,常にシュワン細胞と共在し,神経線維保護機能や痛みのコントローへの関与が示唆された。また,マクロファージの表現型は細胞外基質の影響を受けていることが明らかとなった。一方,長年に渡り論争の的となってきた歯髄リンパ管の存在は,ラミニン-332を応用することでその存在が明らかとなり,今後のリンパ管研究に新たな展開が生まれた。

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Published: 2024-01-30  

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