Metagenomic analysis of mothers and newborns to determine periodontal treatment strategies for the development of healthy gastrointestinal microflora.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10157
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: KATO Satsuki 北海道医療大学, 歯学部, 講師 (50281283)
• Co-Investigator(Kenkyū-buntansha): 長澤 敏行 北海道医療大学, 歯学部, 教授 (90262203) ; 植原 治 北海道医療大学, 歯学部, 講師 (00709248) ; 古市 保志 北海道医療大学, 歯学部, 教授 (80305143)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: メタゲノム解析 / 歯周病治療 / 妊婦 / 切迫早産 / 消化管細菌叢 / 新生児 / プロゲステロン / エストロゲン

Outline of Final Research Achievements

Gingival inflammation and levels of female hormones were compared between healthy and threatened premature delivery pregnant women. Threatened premature delivery pregnant women had more exacerbated gingivitis than healthy pregnant women. In addition, the inflammatory symptoms were associated with a shorter gestational age and a lower birth weight. Differences were observed in the composition of the oral microbiota of the two groups. Furthermore, these changes may be associated with a decrease in progesterone levels.

Free Research Field

歯学

Academic Significance and Societal Importance of the Research Achievements

母親の口腔細菌叢の全身と子への影響を検討し、母親の健康な口腔細菌叢の維持が新生児の健康に果たす影響について明らかにできれば、医科歯科に限らず健康増進のための方策としての波及効果が高い。