2021 Fiscal Year Final Research Report
Morphologically faithful reconstruct the of the jawbone with 3D printed absorbable trays and the cultured periosteal cell graft
Project/Area Number |
19K10165
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
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Research Institution | Niigata University |
Principal Investigator |
Masaki Nagata 新潟大学, 医歯学総合病院, 特任教授 (10242439)
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Co-Investigator(Kenkyū-buntansha) |
川瀬 知之 新潟大学, 医歯学系, 准教授 (90191999)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 3Dプリント / 顎骨再建 / 細胞親和性移植材 / 培養骨膜細胞 |
Outline of Final Research Achievements |
We investigated the potential of 3D print-αTCP trays in jawbone reconstruction, the effectiveness of the cell-affinitive recombinant RGD peptide as a transplant base material, and the effect of cultured periosteal cells on bone formation. Human cultured periosteal cell transplantation into nude rats was encapsulated in a substrate placed in a 3D printed-αTCP tray. Histological observations showed rare bone formation. This is considered to be due to the lack of bone-inducing activity of the transplant material. Although the αTCP tray showed no abnormal inflammatory cells or findings of tissue destruction. The 3D printed-αTCP tray was not toxic, suggesting its usefulness in jawbone regeneration due to its advantages in buildability of individual bone form. This is considered to be due to the lack of bone-inducing activity of the transplant material. The 3D printed-αTCP tray was not toxic, suggesting its usefulness in jawbone regeneration due to its morphogenic advantages.
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Free Research Field |
口腔外科
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Academic Significance and Societal Importance of the Research Achievements |
培養自家骨膜による顎骨再生は 「骨形成能」 を基本とする再生療法であり、骨形成能は細胞療法によってのみ獲得できる効果であり、これによって広範囲かつ複雑な骨再生を期待することができる。αTCPの3Dプリント技術はオーダーメイド人工骨として用いられつつあるが、本研究計画ではこれを造形性の高い顎骨再建トレーとして用いる。 骨再生細胞療法のアドバンテージ と 3Dプリント-αTCP吸収性再建トレーの形態再現性の融合はこれまでに類のない試みである。いずれも臨床段階にある技術であることから、将来、広範囲かつ複雑な形態の顎骨再生を低侵襲で実現することが期待される。
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