Photofunctionalization improves bone integration in the implant body in a long-term administration model of bone resorption inhibito

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10214
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: MAIDA Takeo 北海道医療大学, 歯学部, 教授 (40229282)
• Co-Investigator(Kenkyū-buntansha): 會田 英紀 北海道医療大学, 歯学部, 教授 (10301011)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯学 / 生体材料 / インプラント / 骨粗鬆症 / 骨吸収抑制薬 / 光機能化処理

Outline of Final Research Achievements

The purpose of this study is to investigate the effectiveness of photofunctionalization treatment of implants in rat models in which the bone metabolic ability of the whole body has decreased due to administration of bone resorption inhibitors or ovariectomy. The results of the biomechanical push-in test, micro-CT analysis, and histological observation in ovariectomized rats confirmed that the photofunctionalization treatment of the implant is effective for animal models in which the bone metabolic ability of the whole body is reduced. The results of this study suggest the possibility of improving the treatment outcomes of patients with reduced bone metabolic ability of the whole body.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

骨吸収抑制薬の投与や骨粗鬆症の罹患はインプラント治療におけるリスクファクターとされている。本研究の遂行により、全身の骨代謝能が低下したラットにおける光機能化処理の有効性が示されることから、骨吸収抑制薬の投与や骨粗鬆症罹患患者のインプラント治療成績を向上させる可能性がある。