2022 Fiscal Year Final Research Report

Basic study on the development of combination therapy with the lithotripsy and double litholysis using protein and calcic dissolution liquid under sialendoscopy

Research Project

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Project/Area Number	19K10273
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57060:Surgical dentistry-related
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	NAKAYAMA Eiji 北海道医療大学, 歯学部, 教授 (60172467)
Co-Investigator(Kenkyū-buntansha)	佐野友昭北海道医療大学, 歯学部, 講師 (20244866) 田代真康北海道医療大学, 歯学部, 任期制助手 (20758338) 根津尚史北海道医療大学, 歯学部, 准教授 (40264056) 志茂剛北海道医療大学, 歯学部, 教授 (40362991) 永易裕樹北海道医療大学, 歯学部, 教授 (90265075) 杉浦一考北海道医療大学, 歯学部, 助教 (90529398)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	唾石 / 溶解療法 / 唾液腺内視鏡 / 唾液腺内視鏡下唾石溶解療法 / クエン酸 / 次亜塩素酸ナトリウム
Outline of Final Research Achievements	A citric acid aqueous solution and a sodium hypochlorite aqueous solution were used as salivary stone dissolution solutions. Dried salivary stones were immersed in a citric acid solution, and dissolution was recorded over time. As a result, it was confirmed that the salivary stones gradually dissolved while foaming. A dissolution experiment with sodium hypochlorite was also conducted. As a result, it was confirmed that salivary stones were rapidly dissolved by 5% sodium hypochlorite aqueous solution. The sodium hypochlorite aqueous solution had a higher dissolution effect than the citric acid solution. Therefore, the combined use of citric acid and sodium hypochlorite aqueous solution was expected to enhance the antibacterial effect and shorten the action time.
Free Research Field	歯科放射線学
Academic Significance and Societal Importance of the Research Achievements	我々が目指している唾液腺内視鏡下唾石溶解療法は国内外で今まで報告はなく、国際的にも挑戦的な新規研究である。世界的に最先端の研究であり、不明な点が多い。しかし、今回の予備的研究により、クエン酸や次亜塩素酸ナトリウムを使用して、唾石の溶解が実際に可能であることを確認した。この成果は、臨床的に唾液腺内視鏡下唾石溶解療法を可能にする第一歩の研究として極めて意義深い。さらに、クエン酸水溶液と次亜塩素酸ナトリウム水溶液との併用で抗菌効果の増強と作用時間の短縮、および生体為害性の低減が期待される。唾液腺内視鏡下唾石溶解療法の実用化に向け、さらなる研究が必要である。