2022 Fiscal Year Final Research Report
Investigation of the effects of abnormal mitochondrial dynamics on salivary gland function.
| Project/Area Number |
19K10287
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | ミトコンドリア / 唾液腺 / Tmem135 |
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| Outline of Final Research Achievements |
Tmem135 is a gene that regulates mitochondrial dynamics. In this study, we investigated the involvement of mitochondrial dynamics in salivary secretion by examining the salivary function of Tmem135 mutant mice and Tmem135 transgenic mice (Tg). The results showed a decreasing trend in salivary secretion in Tmem135 mutant mice and an increasing trend in salivary secretion in Tmem135Tg mice, suggesting that Tmem135 is a gene related to the salivary secretion mechanism and that mitochondrial dynamics may also be involved in salivary secretion.
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| Free Research Field |
歯科麻酔学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究はTmem135遺伝子およびミトコンドリアダイナミクスが唾液分泌機能に関わっている可能性を示した最初の報告である。唾液分泌機構はまだまだ解明されていない点が多く、臨床現場においても唾液分泌減少による口腔乾燥症には有効な治療法はなく、多くの臨床医がその対応に苦慮している。本研究成果は唾液分泌の制御機構を解明するための新たな糸口となる可能性がある
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