The elucidation of the inhibitory mechanism of bone resorption by controlling bioactive lipids and these receptors leading to the therapeutic application.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K10340
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Hikiji Hisako 九州歯科大学, 歯学部, 特任教授 (50292876)
• Co-Investigator(Kenkyū-buntansha): 有吉 渉 九州歯科大学, 歯学部, 教授 (40405551)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 口腔外科学一般 / 生理活性脂質

Outline of Final Research Achievements

I have revealed that bioactive lipids are important for bone resorption, and that the inhibition of lipid receptors (GPCR) are therapeutically useful. However, the mechanism of the release of lipid out of cells and the successive reaction of GPCR are still unknown. The object of this study is to clarify the signaling function of the GPCR-relating bioactive lipids to achieve the treatment using the antagonists of bioactive-lipid receptors or the treatment by controlling the production of bioactive lipids.
I have investigated the enzymes relating to the production of bioactive lipids and revealed that lysophospholipid acyltransferases (containing PAF synthetases) are related to the differentiation of bone-relating cells and participated in the control of bone inflammation.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

申請者は、生理活性脂質合成に関わる酵素群の研究を行い、骨代謝機構における重要性を示したので、学術的意義は大きいと思われる。また、「生理活性脂質の受容体アンタゴニストを用いた」治療、あるいは「生理活性脂質産生制御による」治療などへの糸口を開いたので、社会的意義が大きいと思われる。