Identification of targetable genetic mutations and establishment of personalized therapy in standard therapy-resistant oral squamous cell carcinoma

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Keio University
• Principal Investigator: Asoda Seiji 慶應義塾大学, 医学部(信濃町), 講師 (80296706)
• Co-Investigator(Kenkyū-buntansha): 森川 暁 慶應義塾大学, 医学部(信濃町), 講師 (00424169) ; 黄地 健仁 慶應義塾大学, 医学部(信濃町), 助教 (30803564) ; 吉川 桃子 慶應義塾大学, 医学部(信濃町), 講師(非常勤) (50570967) ; 佐谷 秀行 慶應義塾大学, 医学部(信濃町), 名誉教授 (80264282)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 口腔扁平上皮癌 / 遺伝子パネル検査 / CD44v

Outline of Final Research Achievements

We performed a study of the results of gene panel testing performed on specimens of oral squamous cell carcinoma operated on in our department and the differences in histopathology, and found a correlation between the number of Actionable mutations and grade of malignancy. In other words, the higher the number of Actionable mutations, the higher the grade of WPOI classification, which indicates clinicopathologic malignancy.

Free Research Field

口腔がん

Academic Significance and Societal Importance of the Research Achievements

Actionable変異数が予後や治療抵抗性を規定する指標となり得るかについて検討し、Actionable変異数やCD44v関連分子に基づいた発現プロファイルを構築することにより、治療開始前に予後や化学放射線療法の有効性を予測できる個別化治療法の確立を目指している。