2022 Fiscal Year Final Research Report

Can increased stress response in adult rats that were associated with immobilization stress in early postnatal period be relieved?

Research Project

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Project/Area Number	19K10396
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57070:Developmental dentistry-related
Research Institution	Hokkaido University
Principal Investigator	YOSHIHARA TOSHIHIRO 北海道大学, 歯学研究院, 准教授 (60261319)
Co-Investigator(Kenkyū-buntansha)	大島昇平北海道大学, 大学病院, 講師 (00374546) 高崎千尋北海道大学, 歯学研究院, 助教 (60451449)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	身体抑制 / 中枢神経系 / ラット
Outline of Final Research Achievements	It is well known that stress response in adult rats is increased when they were subjected to immobilization stress in early postnatal period. In this study, several experiments were performed by using neuroendocrinological method such as turn-over rate of catecholamines, expression of CRH-productive cells, molecular biological method such as expression of glucocorticoid receptors and click gene, and behavioral science method such as open field test and adial 8-arms maze test. This study suggests that environmental enrichment might relieve increased stress response in these rats.
Free Research Field	小児歯科学
Academic Significance and Societal Importance of the Research Achievements	本研究成果より、身体抑制が成長後の中枢神経系機能に影響することが示され、身体抑制具を用いる上での問題点のエビデンスとなり、小児歯科学・障害者歯科学の発展に大きく寄与するものである。また、中枢神経系機能への影響を緩和する方策の道筋も本研究により示されたので、今後、身体抑制のよる人体への影響を和らげる研究の発展が期待される。