inhibition of orthodontically induced root resorption by HIF-1a inhibition

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10407
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Nagasaki University
• Principal Investigator: Hashimoto Megumi 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80724517)
• Co-Investigator(Kenkyū-buntansha): 佛坂 由可 長崎大学, 病院(歯学系), 講師 (10244089) ; 佛坂 斉祉 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (90199513) ; 近藤 崇伸 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (20814106)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: hif-1a / 歯根吸収 / 矯正

Outline of Final Research Achievements

The purpose of this study was to investigate the involvement of HIF-1α (hypoxia inducible factor 1 alpha) in orthodontic force-induced root resorption from the viewpoints of hyalinization (ischemic cell death) and odontoclast and osteoclast differentiation and activation mechanisms. When HIF-1α inhibitor was intraperitoneally administered to rats and the effect of HIF-1α inhibition was examined, a decrease in hyalinization degenerative tissues was observed, and both odontoclasts and odontoblasts showed a tendency to decrease. However, no significant difference was observed. We will continue the further experiments using a new HIF-1α inhibitor.

Free Research Field

歯科矯正

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、低酸素環境で活性化する転写因子;HIF-1α(hypoxia inducible factor 1 alpha)に注目し、矯正力負荷時の歯根吸収発症の過程に関与するかどうかを検討することである。この研究により、歯根吸収のメカニズムが明らかになることで、矯正治療における最も良くおこる副作用である歯根吸収の予防に繋がる可能性が考えられる。