2021 Fiscal Year Final Research Report
Creation of enamel-like structure under biological simulated environment using nanoparticles and their antibacterial properties
| Project/Area Number |
19K10410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57070:Developmental dentistry-related
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | バイオガラス / ナノ粒子 / 酸化亜鉛 / ペプチド / フォルダマー |
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| Outline of Final Research Achievements |
In this study, bioactive glass (BGnp) and Zinc oxide nanoparticles were synthesized and investigated the enamel remineralization and antibacterial properties. In addition, dynamic foldamer based on hybrid peptides with nitrogenous pyridine was synthesized and surface functionalized BG was immobilized with the foldamer. The BGnp showed excellent acid buffering capacity.
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| Free Research Field |
歯科矯正学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、エナメル質初期う蝕を効率的に再石灰化させるため、比表面積効果によりミネラルの供給を飛躍的に向上させるバイオガラスのナノ粒子化を試みた。加えて、亜鉛ナノ粒子との複合化により抗菌性を獲得した。さらに、バイオガラスナノ粒子によるエナメル質の再石灰化および結晶形成機能を向上させるため、超分子的な手法により、低分子のペプチドフォルダマーとバイオガラスナノ粒子との複合体の創製を試みた。
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