A research for investigating the mechanism how highly pathogenic oral bacteria induces eosinophilic esophagitis.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10463
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Shimane University
• Principal Investigator: Niibayashi Tomomi 島根大学, 医学部, 技術専門職員 (50529675)
• Co-Investigator(Kenkyū-buntansha): 臼田 春樹 島根大学, 学術研究院医学・看護学系, 助教 (30707667) ; 石原 俊治 島根大学, 学術研究院医学・看護学系, 教授 (80263531) ; 和田 孝一郎 島根大学, 学術研究院医学・看護学系, 教授 (90263467)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯周病原因性菌 / streptococcus mutans / Neisseria / 好酸球性食道炎

Outline of Final Research Achievements

Streptococcus mutans (S.m) and Porphyromonas gingivalis (P.g) are hypathogenic oral bacteria which can cause dental caries and periodontitis respectively. Our present study has demonstrated that patients who suffer from eosinophilic　esophagitis tend to show higher detection rate of S.m and P.g in their oral cavity compared to that in healthy subjects. Besides, population of Neisseria mucosa, a commensal oral bacteria is negatively correlated to mumber of eosinophils in　esophagus of EoE patients. These results suggest that environment within oral cavity of EoE patients is suitable for growth of sevelal types of oral bacteria including hypathogenic ones, that possibly affects disease state of EoE.

Free Research Field

全身疾患と口腔内細菌との関連性

Academic Significance and Societal Importance of the Research Achievements

我々は口腔内細菌が様々な全身疾患の潜在的な発症リスク因子となりうるという仮説のもとに検討を行ってきた。これは昨今の腸内細菌の研究コンセプトに類似しているものであるが、口腔内細菌での検討は非常に少ない。本研究は種々の全身疾患と口腔内細菌との関連を明らかにすることで、口腔ケアの重要性を理論的に示すと同時に、将来的に疾患リスクの低減や医療費の削減に資するための基礎的な知見を提供する意義をもつ。