The development of a new preventive method for periodontitis by immune regulation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K10470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Kanagawa Dental College
• Principal Investigator: Sato Takenori 神奈川歯科大学, 歯学部, 講師 (40638904)
• Co-Investigator(Kenkyū-buntansha): 浜田 信城 神奈川歯科大学, 歯学部, 教授 (20247315) ; 渡辺 清子 神奈川歯科大学, 歯学部, 准教授 (70148021) ; 合田 征司 大阪歯科大学, 歯学部, 教授 (70351476)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 歯周病 / サイトカイン / 歯槽骨吸収抑制 / 細菌 / 破骨細胞 / 抗体

Outline of Final Research Achievements

Interleukin-17 (IL-17) is one of the inflammatory cytokines on periodontal disease. The present study was evaluated the bacterial growth inhibitory effect of anti-IL-17-recepter antibody against periodontal bacteria. Moreover, we investigated the influence of anti-IL17-recepter antibody on alveolar bone resorption. As a result, the anti-IL-17-recepter antibody was inhibited the growth of periodontal bacteria in vitro. In an animal model, this antibody was decreased neutrophils and osteoclasts of periodontal tissue and inhibited alveolar bone resorption. These results indicated that the administration of anti-IL-17-recepter antibody inhibited inflammation of periodontal tissue. Therefore, we suggest promote the prevention of periodontal disease.

Free Research Field

口腔生化学

Academic Significance and Societal Importance of the Research Achievements

抗IL-17 抗体が歯周病原細菌の感染抑制と歯周組織への炎症波及の軽減につながれば、歯周病予防に貢献するものと考えられる。また歯周病が全身疾患と関連性と深くIL-17の関与が指摘されている事から、本研究成果は口腔と全身の免疫力向上による健康増進につながると考えている。