2022 Fiscal Year Final Research Report
Exploratory study of factors inducing tongue microbiota transition in the elderly for the prevention of pneumonia
| Project/Area Number |
19K10473
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57080:Social dentistry-related
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
沖永 敏則 大阪歯科大学, 歯学部, 教授 (60582773)
南部 隆之 大阪歯科大学, 歯学部, 講師 (80367903)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 高齢者 / 口腔健康 / 細菌叢 |
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| Outline of Final Research Achievements |
The aim of this study was to find a method for transitioning the bacterial microbiota of the elderly to a healthy type without human intervention trials, by combining our oral microbiota culture model, which can be cultured while maintaining the microbiota composition, with next-generation sequencing technology. As a result, the conditions under which the bacterial microbiota changes significantly with oxygen concentration and pH were clarified. It is hoped that this study will contribute to the development of a method to reduce the risk of pneumonia-related deaths by changing the tongue microbiota of the elderly.
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| Free Research Field |
高齢者歯科学
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| Academic Significance and Societal Importance of the Research Achievements |
高齢者の誤嚥性肺炎発症リスクの低下を目指し，社会的支援が行われていくなかで，摂食嚥下機能の向上，新規の口腔ケア手法の開発など，多面的な研究が並行して進められてきている．また，口腔細菌叢のタイプと肺炎関連死のリスクが関連することが最近報告されてきている．本研究により，「高齢者の舌菌叢を変える」複数の方法の一端を提示することができた．今後，肺炎予防を含めた様々な口腔疾患，全身疾患の予防・治療法を開発する一助となることが期待される．
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