2023 Fiscal Year Final Research Report

Relationship between oxidative stress and sensory nerve hyperextension: a neuroanatomical study using a mouse model of bedsore compression

Research Project

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Project/Area Number	19K10835
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 58050:Fundamental of nursing-related
Research Institution	Showa University
Principal Investigator	Inoue Yuriko 昭和大学, 医学部, 講師 (50509958)
Co-Investigator(Kenkyū-buntansha)	井上明男京都大学, 医学研究科, 非常勤講師 (80107060) 澤智華昭和大学, 医学部, 講師 (80422541) 伊藤純治昭和大学, 保健医療学部, 教授 (90159880) 高木孝士昭和大学, 大学共同利用機関等の部局等, 准教授 (10774820) 森山浩志昭和大学, 医学部, 兼任講師 (20191059) 江連博光昭和大学, 医学部, 准教授 (20267230) 畑春実帝京平成大学, 薬学部, 教授 (00396441) 馬目佳信東京慈恵会医科大学, 医学部, 教授 (30219539) 大塚成人昭和大学, 医学部, 教授 (90296947) 高柳雅朗埼玉県立大学, 保健医療福祉学部, 准教授 (80287523) 田中美香子横浜国立大学, 大学院工学研究院, 助手 (00467060) 山澤徳志子東京慈恵会医科大学, 医学部, 教授 (00282616)
Project Period (FY)	2019-04-01 – 2024-03-31
Keywords	褥瘡
Outline of Final Research Achievements	Decubitus ulcers are thought to be caused by blood flow obstruction and physical stress on the epidermal skin, which increases oxidative stress and causes inflammation and itching. However, most of today's drugs for bedsores are aimed at moisturizing and anti-inflammatory effects, and there are currently no therapeutic agents focused on and specialized for antioxidant effects. We investigated this in a mouse model of bedsore. Vitamin C and vitamin E adsorbed collagen sponges were made by overnight infiltration in 2 ml of each solution. The collagen sponge containing vitamin C and vitamin E was administered to the bedsore site on the day after the magnet was attached, and the progress was observed. Further analysis of the progression of bedsore repair is currently underway with an increased number of cases.
Free Research Field	脳神経科学
Academic Significance and Societal Importance of the Research Achievements	褥瘡は、血流阻害や表皮の皮膚の物理的ストレスが酸化ストレスを高め、炎症や痒みを引き起こすと考えられるが、今日の褥瘡用薬剤は保湿や抗炎症作用を目的としたものが多く、抗酸化作用に焦点をあて特化した治療薬は現状ではない。褥瘡モデルマウスを作成して酸化ストレスが知覚神経細胞に与える影響を分子細胞、組織レベルを調べた。その上で抗酸化作用が褥瘡治癒に対する有効性が見られた。