2021 Fiscal Year Final Research Report
Suppressing sweet taste preferences by improving the oral environment via umami taste stimulation
Project/Area Number |
19K10851
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 58060:Clinical nursing-related
|
Research Institution | Tottori University |
Principal Investigator |
SAKAI Chieko 鳥取大学, 医学部, 助教 (90734327)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Keywords | 2型糖尿病 / 味覚 |
Outline of Final Research Achievements |
Patients with type 2 diabetes are at high risk of low salivary volume and periodontal disease and may have taste disorders. In this study, we investigated whether umami taste stimulation is effective in improving the oral environment and lowering the sweet taste preference of patients with type 2 diabetes. Results showed that, in patients with type 2 diabetes, the intake of umami substances tended to increase salivary output and significantly decrease body weight, BMI, FBS, and TNF-α. These findings suggest that umami stimulation may effectively reduce preferences for sweet taste and improve disease conditions in patients with type 2 diabetes.
|
Free Research Field |
糖尿病
|
Academic Significance and Societal Importance of the Research Achievements |
糖尿病研究の多くは、糖尿病病態のメカニズムやそれに基づいた治療薬の有効性についての検討が主である。医療費の問題や実際の臨床現場に即した治療としては、食事指導に基づいた食習慣の改善を図ることが有効であり、増え続ける糖尿病者(予備軍)に歯止めをかける手段としても重要である。うま味刺激に注目し且つ、社会状況(医療費問題、患者主導の治療)に即した食事指導としては、これまでにない着眼点であり、国内外を問わず、報告はない。本研究により食事指導による新規治療法確立の先駆けとなる事が期待される。
|