Selection criteria for airway clearance care based on the evaluation of bulbar symptom and respiratory function in Amyotrophic Lateral Sclerosis

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K10896
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58060:Clinical nursing-related
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: MATSUDA chiharu 公益財団法人東京都医学総合研究所, 社会健康医学研究センター, 主任研究員 (40320650)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 筋萎縮性側索硬化症 / 人工呼吸 / 球麻痺 / 呼吸障害 / 気道ケア / 苦痛緩和

Outline of Final Research Achievements

To establish respiratory care methods and provide nursing care to alleviate painful symptoms for Amyotrophic Lateral Sclerosis (ALS) patients in clinical course, this study is to reveal the relation of respiratory function and symptoms of bulbar.The study shows:1.Tongue thickness (ultrasonography) of ALS patients can be one of the indicators of disease progression and its relevance to organs involved in dysphagia.　2.The tongue pressure at the initial stage of outpatients shows the relation of respiratory function, globus palsy symptoms and body mass index.That can be a clinical indicator reflecting disease progression.　3. There are diverse symptoms mixed when the patients use noninvasive ventilation and opioids are required, so treatments and care based on careful symptom identification are significant in this period.

Free Research Field

難病看護

Academic Significance and Societal Importance of the Research Achievements

ほぼ全例の筋萎縮性側索硬化症(ALS)患者に必発しているものの、これまで球麻痺症状と呼吸障害の関係を臨床経過の中で詳細に明らかにする研究はほとんどなく、対応策については手つかずであった。さらに、気道ケアは、重度の障害を呈するALSをはじめとして、多くの難病患者に共通する課題であり、生活の質の維持・向上、合併症の予防、生命予後の改善などの成果をもたらすものと期待され、意義が大きいと考える。