2023 Fiscal Year Final Research Report
Basic study of cell therapy development and wound-healing mechanism for pressure ulcer
Project/Area Number |
19K10898
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 58060:Clinical nursing-related
|
Research Institution | Yamagata University |
Principal Investigator |
|
Project Period (FY) |
2019-04-01 – 2024-03-31
|
Keywords | 褥瘡 / 炎症 |
Outline of Final Research Achievements |
This study showed the relationship between the exacerbation of pressure ulcers, and ischemia-reperfusion injury or the initiation of oxidative stress in vivo using animal models. It was suggested that the progression of pressure ulcers is affected by a decrease in nitric oxide production at the wound site and a deficiency of ascorbic acid in the body. For the healing of pressure ulcers, application of hydrocolloid dressings was shown to be effective in promoting wound repair and regeneration with regression of myofibroblasts. In addition, it was suggested that administration of ascorbic acid may be useful in improving the inflammatory reaction of pressure ulcers.
|
Free Research Field |
医歯薬学
|
Academic Significance and Societal Importance of the Research Achievements |
褥瘡の発生・進行に係わる虚血再灌流障害や酸化ストレス亢進について、動物モデルを用いて創部における一酸化窒素産生量の低下と生体のアスコルビン酸欠乏の視点から示した。また褥瘡の治癒にハイドロコロイドドレッシング材貼付の有用性を示した。これらは褥瘡の創治癒機序の解明と新規治療法の開発に学術的意義がある。褥瘡の予防法や治療法の進歩に関連する研究は、褥瘡を患う人々のQOLの改善を目指す上で社会的意義がある。
|