Development of pulmonary rehabilitation method using local oxidative stress markers for idiopathic pulmonary fibrosis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Hiroshima University
• Principal Investigator: Sekikawa kiyokazu 広島大学, 医系科学研究科(保), 准教授 (30363055)
• Co-Investigator(Kenkyū-buntansha): 馬屋原 康高 広島都市学園大学, 健康科学部, 准教授(移行) (60746395)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 呼吸リハビリテーション / 特発性肺線維症 / 局所酸化ストレス

Outline of Final Research Achievements

The purpose of this study was to clarify the validity of methods for analyzing samples of local oxidative stress in patients with idiopathic pulmonary fibrosis (IPF), its influencing factors, and to establish the usefulness of local oxidative stress indicators necessary for developing new strategy of pulmonary rehabilitation programs. In the elderly, estimation of low-intensity daily activities using an activity meter was shown to be a valid measure of physical activity. In addition, it was found that 12 weeks of pulmonary rehabilitation was effective in improving exercise function, reducing shortness of breath, improving health-related quality of life, and increasing daily physical activity in patients with IPF.
Although this study was able to validate the effects of pulmonary rehabilitation in IPF patients, main research results could not be obtained due to the impact of the new coronavirus infection and problems with the investigator.

Free Research Field

呼吸リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

活動量計による歩行以外の低強度身体活動強度の推定は、妥当性の高い測定が可能であることが示され、特発性肺線維症に対する呼吸リハビリテーションの効果判定の基盤となる日常生活活動全般における活動量計測が的確に計測できることが明らかとなった。
当該患者の身体活動をはじめ運動機能向上のための12週間のリハビリテーションプログラムを確立することができた、社会的意義のある研究成果を得ることができた。一方、当該患者に対する呼吸リハビリテーション実施による生体防御機能向上の学術的意義は明らかにすることができなかった。