2021 Fiscal Year Final Research Report
Preventitive Effect of amyloid beta production in Alzheimer's disease by myokines after exercise
| Project/Area Number |
19K11415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | アルツアイマー病 / アミロイドβ / 老人斑 / 運動 / マイオカイン |
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| Outline of Final Research Achievements |
Exercise therapy as an intervention in Alzheimer's disease has received much attention from the results of epidemiological studies. We focused here on the involvement of myokines released from muscle. It was shown that FNDC5, a type of myokines, competitively binds to BACE1 at the β-cleavage site of APP to reduce the activity of BACE1 and, as a result, reduce the production of Aβ40, 42. When exercise produces FNDC5 from muscles, it may be cleaved into a short peptide, irisin, that circulates in the blood and acts on nerve cells (by an unknown mechanism) to suppress Aβ production. It is presumed that this may be one of the mechanisms for preventing the progression of Alzheimer's disease by exercise.
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| Free Research Field |
神経内科学
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病は現時点では根治療法がなく、現在開発されている治験薬も非常に効果であると言われている。また長期における副作用も懸念される。今後、高齢化の進行により、アルツハイマー病患者がさらに増加することは確実であり、運動療法のように、効果的かつ副作用のない介入が求められる。本研究のように、運動療法の効果の機序を解明することは、将来的にエビデンスを持った介入の確立に重要であり、新たな創薬のターゲットとなり得る。
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