Effect of habitual physical activity on circulating natriuretic peptide levels

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K11441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Saga University
• Principal Investigator: Nishida Yuichiro 佐賀大学, 医学部, 講師 (50530185)
• Co-Investigator(Kenkyū-buntansha): 田中 恵太郎 佐賀大学, 医学部, 教授 (50217022) ; 原 めぐみ 佐賀大学, 医学部, 准教授 (90336115)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 身体活動

Outline of Final Research Achievements

It has been reported that higher circulating NT-proBNP is associated with an increased risk of mortality. A cross-sectional analysis of accelerometer-assessed physical activity and blood NT-proBNP in the participants of the Saga J-MICC Study (1,824 men and 2,789 women) showed that the replacement of 60 minutes of sedentary behavior with 60 minutes of moderate-to-vigorous intensity activity resulted in a 23% reduction in the circulating NT-proBNP in men. The replacement effect was more clearly seen in men who drank more (>23 g/day) than men who drank less or no alcohol. In conclusion, the present results suggest that the replacement of sedentary behavior with moderate-to-vigorous intensity activity may reduce the circulating NT-proBNP levels in men. The present results also suggest that the replacement effect of sedentary behavior with moderate-to-vigorous intensity activity may be modified by alcohol drinking status in men.

Free Research Field

分子疫学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果より、男性において、座位行動（座っている時間）を中高強度活動（歩行レベル以上）に置き換えることにより、血中NT-proBNP濃度が減少する可能性が明らかになった。この負の関連は、歩行レベル未満の低強度活動では見られておらず、中高強度活動の重要性が示唆された。また、飲酒量の多い男性において、血中NT-proBNP濃度を低下させる座位行動から中高強度活動への置き換え効果がより明確に認められた。この結果より、血中NT-proBNP濃度を減少させる中高強度活動のベネフィットが、様々な疾患の発症リスクを上昇させる飲酒習慣がある男性において特に大きい可能性が示唆された。