2021 Fiscal Year Annual Research Report
Development of optimal exercise therapy to prevent diabetes induced multiple organ complications: a focus on VEGF
| Project/Area Number |
19K11543
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
渡部 厚一 筑波大学, 体育系, 准教授 (30447247)
河野 了 筑波大学, 医学医療系, 講師 (90323295)
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | 糖尿病 / 合併症 / 運動 |
|---|
| Outline of Annual Research Achievements |
n this project, we focused on animal and human studies at different stages of diabetes with different types of diabetes. We used various types of exercise regimens both in animal and human subjects with diabetes. One of our crucial findings is that if we can detect the pre-diabetes stage and start soon even mild exercise, this exercise can significantly prevent or delay the diabetes development from the pre-diabetes stage. A sizeable human cohort study is going on. We already know that VEGF signaling is a crucial signaling altered organ-dependently at the early stage of diabetes. This altered VEFG signaling is the crucial factor in initiating diabetic complications. Here both from animal and human studies, we found that various types of exercise regimens work effectively through VEGF system modulation in different organs at various stages of diabetes.
In some cases, exercise prevents diabetes-organ complications through VEGF system upregulation, and also exercise arrests diabetic organ complications through VEGF system suppression. In this research, we used two types of diabetes models: one is OLETF rats, and another is the high fatty diet-induced diabetic model. In human studies, we measured biochemical diabetic parameters before and after exercise. In addition, we assessed cognition, cardiac parameters, renal parameters, and eye function before and after exercise. Lifestyle medicine plays a crucial role through lifestyle medication to combat diabetes and its complications, as evidenced in the current study from both animal and human studies pieces of evidence.
|
-
-
-
[Journal Article] Covid-19 Vaccination status in Bogura district in Bangladesh.2022
Author(s)
Jesmin, S.; Maqbool, A.; Sohael, F.; Islam, M.M.; Matsuishi, Y.; Shima, T.; Shimojo, N.; Kawano, S.; Rahman, M.A.; Yamaguchi, N.; Masao, M.
-
Journal Title
Journal of Biomedical Research & Environmental Sciences
Volume: -
Pages: -
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] COVID-19 Community Survey, Knowledge, Attitude and Practice by Bangladeshi Population.2022
Author(s)
Jesmin, S.; Maqbool, A.; Sohael, F.; Islam, M.M.; Matsuishi, Y.; Shima, T.; Shimojo, N.; Kawano, S.; Rahman, M.A.; Yamaguchi, N.; Masao, M
-
Journal Title
Journal of Biomedical Research & Environmental Sciences
Volume: 3(4)
Pages: 367-372
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Covid-19, Co-morbidities and its impact on prognosis in a tertiary care hospital of Bangladesh.2022
Author(s)
Mamun, M.A.; Maqbool, A.; Sohael, F.; Rahman, M.A.; Islam, M.M.; Shima, T.; Shimojo, N.; Kawano, S.; Yamaguchi, N.; Masao, M.; Jesmin, S
-
Journal Title
Journal of Medical - Clinical Research & Reviews
Volume: 6(2)
Pages: 1-5
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Prevalence of Diabetes Mellitus Among Tuberculosis patients in Bangladesh.2022
Author(s)
Mamun, M.A.; Maqbool, A.; Sohael, F.; Rahman, M.A.; Islam, M.M.; Shima, T.; Shimojo, N.; Kawano, S.; Yamaguchi, N.; Masao, M.; Jesmin, S
-
Journal Title
Journal of Diabetes and its Complications
Volume: 6(1)
Pages: 1-8
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] Prevalence of Metabolic Syndrome Components among Early Age onset Acute Coronary Syndrome Patients in Banglades.2021
Author(s)
Jesmin, S.; Maqbool, A.; Sultana, S.N.; Sohael, F.; Islam, M.M.; Matsuishi, Y.; Shima, T.; Shimojo, N.; Kawano, S.; Rahman, M.A.; Yamaguchi, N.; and Moro, M
-
Journal Title
Cardiology & Vascular Research
Volume: 5(4)
Pages: 1-8
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
