Basic research on muscle loss and umami sensitivity disorder in the vicious cycle of frailty syndrome

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11647
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Nakamichi Atsuko 九州歯科大学, 歯学部, 教授 (20567341)
• Co-Investigator(Kenkyū-buntansha): 古株 彰一郎 九州歯科大学, 歯学部, 教授 (30448899) ; 石川 由美 (星野由美) 大阪歯科大学, 医療保健学部, 准教授 (60457314) ; 邵 仁浩 九州歯科大学, 歯学部, 教授 (10285463) ; 本田 尚郁 九州歯科大学, 歯学部, 助教 (10840085) ; 松原 琢磨 九州歯科大学, 歯学部, 准教授 (00423137)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 骨格筋量減少 / うま味感受性 / フレイルサイクル / 若年女性

Outline of Final Research Achievements

In this study, we conducted a survey among young women to clarify the relationship between umami sensitivity and skeletal muscle mass loss. Results showed that more than 40% of patients had low skeletal muscle mass, but no association was observed with umami sensitivity. On the other hand, body fat percentage was suggested to be associated with umami sensitivity. Inosinic acid, which is representative inducer of Umami sensation, strongly induced myoblast differentiation in C2C12, murine myoblast cells. In the future, we will examine the relationship of umami sensitivity with both skeletal muscle and body fat in the elderly.

Free Research Field

口腔保健学

Academic Significance and Societal Importance of the Research Achievements

低栄養の要因である味覚感受性障害を骨格筋量減少との直接の関連から検討する研究は他にない。ヒトの現象でうま味感受性が骨格筋の代謝に影響することが明らかになれば、新たなフレイル予防の試みに繋がる可能性がある。本研究では、若年層における骨格筋減少という新たな問題を明らかにしたが、うま味感受性との関連は確認できなかった。うま味感受性の体組成への影響は各年代の健康課題に資することから引き続き調査を行う。