Elucidation of new molecular mechanism of intracellular proteolytic system in various nutritional states

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11658
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Suzuka University of Medical Science
• Principal Investigator: Tanahashi Nobuyuki 鈴鹿医療科学大学, 保健衛生学部, 教授 (30511927)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: プロテアソーム / 蛋白質分解 / ユビキチン / 分子集合

Outline of Final Research Achievements

When the supply of energy sources from the outside is cut off due to fasting or starvation, our body uses the amino acids produced by decomposing proteins as energy sources in addition to the glycogen and fat stored in the body. The ubiquitin-proteasome system exists as the degradation of this major protein.
In this study, we analyzed the functional changes of this degradation system and the state of the proteasome formed using the liver and brain of fasted mice. As a result, there was no significant difference in the morphology of the proteasome formed between the liver and the brain. However, there were significant differences in the function of the proteasome.

Free Research Field

機能生物化学

Academic Significance and Societal Importance of the Research Achievements

真核生物の細胞内には選択的なタンパク質の分解系と非選択的なタンパク質の分解系が存在する。今回の研究を進めることにより、この栄養状態における２つの分解系の協調性と役割分担の解明に繋がると考えており、さらに正常組織で解析することにより、まだ解明されていないユビキチン・プロテアソーム系と栄養状態が悪化することにより引き起こされる疾患との関係について追及していくことが期待される。