Effect of dietary fibers on the process of absorption and transfer to blood of the therapeutic agent for lifestyle-related disease: Investigation of drug-dietary fiber interaction.

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K11681
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Setsunan University
• Principal Investigator: Iwazaki Ayano 摂南大学, 薬学部, 講師 (20319792)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 食物繊維 / 薬物相互作用 / 糖尿病治療薬 / ビグアナイド / メトホルミン

Outline of Final Research Achievements

We investigated the interaction between dietary fiber and drugs for lifestyle-related diseases, focusing on the amount of the free form of the drug and drug permeation in the small intestine related to the process underlying the drug effect. The amount of free drug was influenced by the type of dietary fiber and related to the solvent condition of the mixture. Mixing a biguanide, a type of drug used to treat diabetes, and sodium alginate, a dietary fiber, decreased the amount of free drug in water and reduced the amount of drug transport through the membrane of Caco-2 cells, which have characteristics of small intestinal epithelial cells. These findings suggest that the potential for drug-fiber interactions should be noted in patients taking drugs simultaneously with supplements rich in dietary fiber.

Free Research Field

薬学

Academic Significance and Societal Importance of the Research Achievements

食物繊維は生活習慣病の発症やそのリスク因子の減少に役立つとされ、いわゆる健康食品や保健機能食品にも利用されている。本研究では、食物繊維と薬の組み合わせによっては遊離薬物量の減少や薬物の小腸細胞での輸送量の減少が生じる結果が得られ、食物繊維と薬の相互作用の一端を明らかにすることが出来た。本研究は、健康食品中の食物繊維の1回摂取量を考慮した実験であり、毎日の服用が必要な生活習慣病の治療薬と食物繊維を含有する健康食品を同時に摂取することには相互作用に注意が必要であることを社会に示すことが出来た。