Verification of pathogenesis and exploring nutritional science approaches of exercise-induced anemia in progressive malnutrition

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K11695
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Kobayashi Yukiko 京都府立大学, 生命環境科学研究科, 講師 (10381930)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: スポーツ貧血 / 高強度運動 / 低栄養 / 運動誘発性溶血 / 鉄代謝 / ビタミン

Outline of Final Research Achievements

In the present study, the mechanisms leading to exercise-induced anemia, including changes in iron metabolism and inflammation, were observed in rats under conditions of reduced food intake or low food intake not commensurate with energy consumption during high-intensity exercise. Furthermore, we investigated the feeding status and changes in iron metabolism during high-intensity exercise in athletes. The results of animal studies suggest that food intake decreases during high-intensity exercise, and that continuous high-intensity exercise load and low dietary intake iron metabolic fluctuations that prioritize blood cell maintenance. And the investigation of athletes confirmed the variation in blood cell status and iron metabolism due to continuous training, and nutrients intake was found to be potentially related to the regulation of iron metabolism.

Free Research Field

栄養科学、スポーツ栄養学、臨床栄養学

Academic Significance and Societal Importance of the Research Achievements

運動誘発性貧血の発症が血管内溶血のみならず慢性炎症による鉄代謝変動や臓器の酸化損傷に影響を受け、それに食事量や食事の質が関わることが明確になれば、運動誘発性貧血解決の一助となる。また本研究から軽度低栄養状態における運動誘発性溶血の発症メカニズムと食事介入の重要性について明示することができれば、適正な栄養状態や運動習慣の定着、身体活動量の増加などを通じた国民の健康増進に向けて大きく貢献できると考えている。