Exercise training for vasospastic angina

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K11762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: International University of Health and Welfare (2020-2021); Tohoku University (2019)
• Principal Investigator: Matsumoto Yasuharu 国際医療福祉大学, 国際医療福祉大学塩谷病院, 教授 (90600528)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 運動療法 / 狭心症 / 冠攣縮 / CT / 運動耐容能 / 冠微小血管障害

Outline of Final Research Achievements

We aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs. In the former protocol, myocardial blood flow(MBF) on CT perfusion was significantly decreased in the VSA group compared with the Non-VSA group. In the latter protocol, exercise capacity was significantly increased in the Exercise group than in the Non-Exercise group. MBF was also significantly improved after 3 months only in the Exercise group, although there were no significant between-group differences. These results provide the first evidence that, in VSA patients, exercise training on the top of CCBs treatment may be useful to improve physical performance, although its effect on MBF may be minimal.

Free Research Field

循環器内科　心臓リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

我々は、冠攣縮性狭心症の病態において、冠動脈の外膜側の炎症が重要な役割を担うことを明らかにしてきた。
冠攣縮性狭心症にしばしば合併する冠微小循環障害を改善しうる定期的運動療法の検討は国内・国外含めて報告がなく、オンリーワンの研究である。本研究結果により、日本や欧米で近年増加している虚血性心臓病の主因の一つである冠攣縮に対する運動生理学的病態の更なる理解および患者の生活の質の向上に大きく寄与しうることが期待される。