2022 Fiscal Year Final Research Report
Reconsideration of the drinking habit of alcoholic liver disease patients from the viewpoint of acetaldehyde-derived advanced glycation end products
Project/Area Number |
19K11803
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Kanazawa Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
堤 幹宏 金沢医科大学, 医学部, 教授 (00155425)
飯田 安保 金沢医科大学, 一般教育機構, 准教授 (10337173)
土島 睦 金沢医科大学, 医学部, 教授 (70197705)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | アルコール性肝障害 / アセトアルデヒド由来終末糖化産物 / AA-AGEs / 終末糖化産物 / アセトアルデヒド / 飲酒 |
Outline of Final Research Achievements |
A total of 73 patients with alcoholic (AL) liver disease (ALD) were investigated to determine whether the amount of acetaldehyde (AA)-derived advanced glycation end-products (AA-AGEs) involved in the development and progression of ALD. We focused on ALDH2 polymorphisms and daily average or cumulative alcohol consumption. A significant weak positive correlation was observed between cumulative alcohol consumption and serum AA-AGEs levels, and serum AA-AGEs levels were higher in patients with alcoholic liver cirrhosis than in other ALD disease types. There was no significant difference in serum and liver tissue AA-AGEs between ALDH2 genotypes. From the above, it was considered that the increase in AA is not necessarily related to the production of AA-AGEs, and the possibility that AA-AGEs affect the development and progression of ALD is low.
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Free Research Field |
肝臓病学
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Academic Significance and Societal Importance of the Research Achievements |
今回、血清AA-AGEs値が積算飲酒量のマーカーになりうる可能性が示唆された。 慢性AL飼育ラットと異なり、ヒトでは様々な飲食物をその時々に摂取しており、AA-AGEs以外のAGEsの関連についても検討を要すると思われる。
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