Novel cell therapy to prevent chronic phase occlusion of endovascular stents

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K12797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Tohoku University
• Principal Investigator: HOSOYAMA Katsuhiro 東北大学, 医学系研究科, 大学院非常勤講師 (70837046)
• Co-Investigator(Kenkyū-buntansha): 齋木 佳克 東北大学, 医学系研究科, 教授 (50372298) ; 鈴木 佑輔 東北大学, 医学系研究科, 助教 (70791698) ; 熊谷 紀一郎 東北大学, 大学病院, 講師 (80396564)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ステント治療 / 再生医療

Outline of Final Research Achievements

The aim of this study was to achieve endothelialization of the stent surface by administering Muse cells with tissue repair capability to treat chronic phase complications such as restenosis, occlusion, and branching vessel occlusion after endovascular treatment.
We performed experiments aimed at preventing coronary stent occlusion and branch occlusion in Multilayered Flow Modulators (MFM) in the chronic phase. The MFM is a new treatment device for aortic aneurysms that has the property of keeping the important branch patent, but requires Antiplatelet therapy. We investigated the possibility of preventing branch occlusion in patients with MFM implantation by administering Muse cells. We prepared MFM tent for a small animal and performed MFM animal model creation. Next, we performed coating of the MFM stent with S1P agonist. After that, mesenchymal stem cell　migration and viability responses were assessed.

Free Research Field

心臓血管外科学

Academic Significance and Societal Importance of the Research Achievements

心血管疾患罹患患者の増加に伴い、冠動脈疾患や大動脈疾患に対するステント治療も増加の一途を辿っている。慢性期における冠動脈ステント狭窄や閉塞、分枝付き胸部・腹部ステントグラフトの分枝閉塞は遠隔期の致命的な合併症である。自己複製能、三胚葉性の分化能などを有するMuse細胞は、閉塞しつつあるステント骨格表面の内皮化を促し、慢性的な血管壁損傷に起因する血栓症やステント再狭窄を改善することが期待される。